Related Experiment Video

Updated: Aug 9, 2026

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix
10:37

Analysis of HBV-Specific CD4 T-cell Responses and Identification of HLA-DR-Restricted CD4 T-Cell Epitopes Based on a Peptide Matrix

Published on: October 20, 2021

[History and presence of hepatitis B and C therapy]

Petr Husa

    Vnitrni Lekarstvi
    |September 22, 2017
    PubMed

    Insights

    Hepatitis B virus (HBV) and hepatitis C virus (HCV) treatments have advanced significantly. Current therapies for chronic hepatitis B focus on managing progression, while new IFN-free regimens offer a cure for chronic hepatitis C with high efficacy.

    Area of Science:

    • Hepatology
    • Virology
    • Infectious Diseases

    Background:

    • Hepatitis B virus (HBV) and hepatitis C virus (HCV) are leading causes of chronic liver disease globally.
    • Significant advancements in understanding pathophysiology, diagnostics, and therapeutics have improved patient care over the past two decades.

    Purpose of the Study:

    • To outline current treatment goals and strategies for chronic hepatitis B (CHB) and chronic hepatitis C (CHC).
    • To highlight the efficacy and advantages of new interferon-free (IFN-free) therapies for CHC.

    Main Methods:

    • Review of current treatment options for CHB, including oral antivirals (tenofovir, entecavir) and pegylated interferon α-2a.
    • Description of CHC treatment aiming for sustained virological response (SVR) using IFN-free regimens.

    Main Results:

    • CHB treatment aims to prevent progression to cirrhosis, decompensation, and hepatocellular carcinoma (HCC), often requiring long-term or lifelong oral therapy.
    • IFN-free regimens for CHC achieve cure rates of 95-100% with minimal side effects and contraindications, representing the current standard of care.

    Conclusions:

    • Treatment strategies for CHB focus on long-term management and disease progression prevention.
    • IFN-free therapies have revolutionized CHC treatment, offering high cure rates and improved patient outcomes.

    More Related Videos

    A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target11:34

    A Competent Hepatocyte Model Examining Hepatitis B Virus Entry through Sodium Taurocholate Cotransporting Polypeptide as a Therapeutic Target

    Published on: May 10, 2022

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA04:11

    Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA

    Published on: December 15, 2023

    Related Concept Videos

    Retrovirus Life Cycles01:10

    Retrovirus Life Cycles

    Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the retrovirus to...
    Pulmonary Tuberculosis V01:28

    Pulmonary Tuberculosis V

    Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
    Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    Hepatitis01:25

    Hepatitis

    Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
    Inhibitors of Viral Protein Synthesis01:30

    Inhibitors of Viral Protein Synthesis

    Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
    Viral Hepatitis I: Introduction01:28

    Viral Hepatitis I: Introduction

    Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...