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MicroRNAs in Atrial Fibrillation
Alexandros Briasoulis1, Shikha Sharma2, Tesfaye Telila1
1Wayne State University, Division of Cardiology, Detroit, Michigan, MI, United States.
Current Medicinal Chemistry
|September 22, 2017
Summary
MicroRNAs regulate gene expression and are crucial in cardiovascular health and disease. This review explores their role in atrial fibrillation, highlighting their potential as biomarkers and therapeutic targets.
Area of Science:
- Molecular Biology
- Cardiovascular Science
- Genetics
Background:
- MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression post-transcriptionally.
- miRNAs play vital roles in cardiovascular system physiology, development, and disease progression.
- Emerging evidence links tissue-specific miRNAs to structural and electrical remodeling in atrial fibrillation (AF).
Purpose of the Study:
- To review the role of microRNAs in the pathogenesis of atrial fibrillation (AF).
- To discuss the potential of miRNAs as biomarkers for AF diagnosis and prognosis.
- To explore miRNAs as potential therapeutic targets for AF treatment.
Main Methods:
- Review of recent animal and human studies on microRNAs in cardiovascular disease.
- Analysis of literature focusing on miRNA expression and function in atrial tissue.
- Synthesis of current knowledge on miRNA involvement in AF-related remodeling.
Main Results:
- Tissue-specific miRNAs are implicated in the structural and electrical remodeling characteristic of AF.
- miRNA expression patterns may serve as indicators of AF development and progression.
- Specific miRNAs show potential for modulation to treat AF.
Conclusions:
- MicroRNAs are significant players in cardiovascular regulation and AF.
- miRNAs represent promising novel biomarkers for atrial fibrillation.
- Targeting microRNAs offers a potential new therapeutic strategy for managing AF.
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