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Smart Organic-Inorganic Nanogels for Activatable Theranostics
Fangyuan Li1,2, Zeyu Liang1,2, Daishun Ling1,2,3
1Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Current Medicinal Chemistry
|September 22, 2017
Summary
Stimuli-responsive polymeric nanogels combined with inorganic nanomaterials create advanced organic-inorganic hybrid nanogels. These nanogels offer dual capabilities for targeted drug delivery and medical imaging, paving the way for enhanced theranostic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Intelligent polymeric nanogels are ideal nanoplatforms for stimuli-responsive drug delivery and controlled release.
- Functional inorganic nanomaterials are widely utilized as medical imaging agents due to their unique magnetic or optical properties.
Purpose of the Study:
- To review recent advances in stimuli-responsive organic-inorganic hybrid nanogels.
- To discuss methods for integrating polymeric nanogels with inorganic nanomaterials.
- To highlight theranostic applications of these hybrid nanogels.
Main Methods:
- Physical and chemical methods for integrating polymeric nanogels and inorganic nanomaterials.
- Review of literature on stimuli-responsive organic-inorganic hybrid nanogels.
- Analysis of activatable theranostic applications.
Main Results:
- Organic-inorganic hybrid nanogels inherit properties from both components, exhibiting stimuli-responsive multi-functionalities.
- Successful integration methods enable the creation of sophisticated nanoplatforms.
- Demonstrated theranostic applications showcase potential for combined imaging and therapy.
Conclusions:
- Stimuli-responsive organic-inorganic hybrid nanogels represent a promising platform for advanced theranostics.
- Further research is needed to address existing challenges and explore future directions in this field.
