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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Skin metastasis: from conceptual to practical guidelines.

Martin R Dittmer¹, Vincent Liu²

¹Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Societa Italiana Di Dermatologia E Sifilografia

|September 22, 2017

Summary

Cutaneous metastases, skin manifestations of visceral malignancy, are challenging to diagnose. This review provides a practical approach to identifying these tumors using clinical and pathological data.

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Area of Science:

Oncology
Dermatology
Pathology

Background:

Cutaneous metastases are outward signs of visceral malignancy.
Diagnosis can be difficult due to rarity and variability.
Clinical suspicion is crucial for identification.

Purpose of the Study:

To provide a practical approach for diagnosing cutaneous metastases.
To emphasize the use of clinical and pathological data.
To highlight common entities and differential diagnoses.

Main Methods:

Review of clinical and pathological data.
Emphasis on differential diagnoses.
Identification of clues for recognition.

Main Results:

Discusses commonly encountered cutaneous metastases.
Provides differential diagnoses for challenging cases.
Highlights metastases of unknown primary and hematolymphoid malignancies.

Conclusions:

Accurate characterization of skin metastases requires integrated clinical and pathological assessment.
High clinical suspicion is essential for timely diagnosis.
Understanding clinicopathologic variability aids in identification.