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Updated: Feb 22, 2026

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
Published on: June 30, 2023
Transcriptional regulation of autophagy and lysosomal function by bromodomain protein BRD4
Jun-Ichi Sakamaki1, Kevin M Ryan1
1a Cancer Research UK Beatson Institute , Glasgow , UK.
Abstract:
Macroautophagy/autophagy is an intracellular recycling system that delivers cytoplasmic organelles and materials to lysosomes for degradation. This process is operated by autophagy-related (ATG) genes and tightly controlled by stress-responsive signaling pathways. Our recent study revealed that autophagy programs are transcriptionally suppressed by the BET family protein BRD4. This repression is alleviated during nutrient deprivation through the AMPK-SIRT1 pathway. Our findings therefore provide new insights into the regulation of autophagy.
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