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Updated: Jan 26, 2026
07:51
Development and Functionalization of Electrolyte-Gated Graphene Field-Effect Transistor for Biomarker Detection
Published on: February 1, 2022
3.8K
Graphene Field Effect Transistors for Biomedical Applications: Current Status and Future Prospects
Rhiannan Forsyth1, Anitha Devadoss2, Owen J Guy3
1Centre for Nanohealth, College of Engineering, Swansea University, Swansea SA2 8PP, UK. 652686@swansea.ac.uk.
Diagnostics (Basel, Switzerland)
|September 22, 2017
Summary
Graphene-based field-effect transistors (G-FETs) show promise for rapid, sensitive, label-free biomedical diagnostics at the point-of-care. This review highlights advancements in G-FET sensor design to overcome limitations for clinical applications.
Area of Science:
- Bioelectronics
- Nanomaterials Science
- Sensor Technology
Background:
- Graphene-based field-effect transistors (G-FETs) have emerged as a significant technology in bioelectronics due to their unique properties.
- Their mass-scalability, low manufacturing cost, and potential for label-free, rapid, and highly sensitive analysis make them attractive for point-of-care diagnostics.
Purpose of the Study:
- This review elucidates recent developments in G-FET sensors for bioaffinity-based detection.
- It focuses on the transduction of biological binding events into electrical signals for analyte quantification.
Main Methods:
- The review examines G-FET sensors that utilize bioaffinity interactions between bioreceptors and target analytes.
- It discusses the principles of signal transduction at the G-FET surface.
Main Results:
- G-FETs offer label-free, rapid, and highly sensitive analysis with high sample throughput.
- Recent developments focus on improving G-FET sensor design for accurate and reliable disease diagnosis.
Conclusions:
- Overcoming limitations such as Debye-Hükel screening and device surface area is crucial for advancing G-FETs in clinical settings.
- Continued research efforts aim to enhance G-FET bioelectronics for improved point-of-care biomedical applications.
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