Related Experiment Video
Updated: Jul 28, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Developmental care, neonatal behavior and postnatal maternal depressive symptomatology predict internalizing problems
R Montirosso1, L Giusti1, P De Carli1
10-3 Centre for the at-Risk Infant, Scientific Institute, IRCCS Eugenio Medea, Lecco, Italy.
Insights
Developmental care (DC) quality impacts preterm infant behavior and maternal mood. Poor DC and maternal depression predict more infant behavioral issues long-term.
Area of Science:
- Neonatal development
- Developmental psychology
- Perinatal mental health
Background:
- Preterm infants face unique developmental challenges.
- Developmental care (DC) practices in neonatal intensive care units (NICUs) aim to support infant well-being.
- Postnatal maternal depression can affect infant outcomes.
Purpose of the Study:
- To develop a prospective model for preterm infant behavioral outcomes.
- To examine the influence of developmental care (DC) quality and maternal depression on these outcomes.
Main Methods:
- Longitudinal, multicenter study in 25 Italian NICUs.
- 162 healthy very preterm infants and their mothers participated.
- Assessed DC quality, infant neurobehavior, and maternal depressive symptoms over time.
Main Results:
- Low-quality DC linked to poorer infant neurobehavioral adaptability and increased maternal depressive symptoms.
- Maternal depression and infant dysregulation predicted more internalizing behavioral problems at 18 months.
Conclusions:
- Developmental care interventions significantly impact infant outcomes.
- Postnatal maternal depression is a critical factor in long-term infant behavioral development.
- Integrated approaches addressing both DC and maternal mental health are crucial.
Objective:
To provide a prospective developmental model for behavioral outcomes in preterm infants in relation to developmental care (DC) practices and postnatal maternal depression.
Study Design:
A longitudinal, multicenter, follow-up study conducted in 25 Italian tertiary neonatal intensive care units (NICUs). Participants were 162 healthy very preterm infants and their mothers. The level of quality of DC was assessed for each hospital. Infant's neurobehavioral profile was evaluated twice: at discharge (T1) and at 18 months for behavioral problems (T3). Maternal depressive symptomatology was measured at T1 and at 6 months (T2).
Results:
Low-quality DC in NICUs was associated with lower levels of infant neurobehavioral adaptability and higher levels of maternal depressive symptoms. Maternal depressive symptomatology in conjunction with higher infant dysregulation predicted more internalizing problems at 18 months of age.
Conclusion:
DC interventions and postnatal maternal depression, as well as infant behavior have an impact on short- and long-term infant outcomes.
Related Concept Videos
The Nativist Approach
Socioemotional Development during Infancy
Primary Temperament Types
Stella Chess...
Attachment
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Oppositional Defiant Disorder
Diagnostic Criteria and...
Relationship with Parents: Attachment

