Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...

Kidney Transplant II: Surgical Procedure

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Imaging Studies I: Kidney, Ureter, and Bladder Studies

Kidney, Ureter, and Bladder (KUB) StudiesKidney, Ureter, and Bladder (KUB) studies are standard diagnostic imaging procedures used to assess the anatomy of the urinary system. They are commonly utilized for patients experiencing abdominal pain or urinary symptoms. By using a simple X-ray of the abdomen, KUB studies can reveal structural and pathological abnormalities within the kidneys, ureters, and bladder. These studies are particularly valuable in diagnosing kidney stones, urinary...

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...

Diabetic Ketoacidosis l: Introduction

Diabetic Ketoacidosis l: Introduction

DefinitionDiabetic ketoacidosis (DKA) is an acute, life-threatening complication of diabetes mellitus, characterized by a triad of hyperglycemia (blood glucose >250 mg/dL), ketonemia or ketonuria, and metabolic acidosis (arterial pH <7.30 and serum bicarbonate <18 mEq/L). It results from insulin deficiency combined with elevated levels of counterregulatory hormones—glucagon, catecholamines, cortisol, and growth hormone—leading to increased lipolysis, hepatic ketone production, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Association of Physical Activity with Impulsivity, Depression and Anxiety Among Patients with Gambling Disorder: A Cross-Sectional Study.

International journal of environmental research and public health·2026

Same author

Variability and Magnitude of Choline Levels Across the Psychosis Spectrum: A Meta-analysis.

Schizophrenia bulletin·2026

Same author

A multicenter study to validate the Brief Cognitive Status Examination as a screening tool for the detection of cognitive impairment in a substance use disorder population over 45 years of age in a Spanish population.

Psychiatry research·2026

Same author

Time to lithium: A case register study of lithium initiation in bipolar disorder.

Journal of psychopharmacology (Oxford, England)·2026

Same author

Clinical characteristics related to suicidal behaviors among outpatients with opioid use disorder: A cross-sectional study.

Journal of opioid management·2026

Same author

Exploring the genetic overlap between substance use disorder and educational attainment.

Addiction (Abingdon, England)·2025

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

Delayed Urinary Symptoms Induced by Ketamine.

María Robles-Martínez^1,2, Alfonso C Abad^1,2, Violeta Pérez-Rodríguez¹

¹a Doctor and Researcher, Addiction and Dual Diagnosis Unit, Department of Psychiatry , Vall d'Hebron University Hospital-Public Health Agency, Barcelona (ASPB), CIBERSAM , Barcelona , Spain.

Journal of Psychoactive Drugs

|September 22, 2017

Summary

This summary is machine-generated.

Ketamine abuse can cause long-term urinary damage, even years after cessation. This case highlights persistent genitourinary symptoms and bladder lesions in a former ketamine user, emphasizing the need for further research.

Keywords:

Addiction bladder delayed ketamine side-effects urinary

More Related Videos

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Related Experiment Videos

Last Updated: Jun 26, 2026

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

A High-performance Liquid Chromatography Measurement of Kynurenine and Kynurenic Acid: Relating Biochemistry to Cognition and Sleep in Rats

Published on: August 19, 2018

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements

Published on: January 7, 2019

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

Area of Science:

Urology
Toxicology
Addiction Medicine

Background:

Ketamine abuse is associated with genitourinary damage.
Long-term sequelae of ketamine abuse require further investigation.

Observation:

A 26-year-old male presented with persistent urinary symptoms including dysuria, frequency, urgency, incontinence, nocturia, hematuria, and suprapubic pain.
Symptoms began two years prior to presentation and progressively worsened.
The patient had a history of daily intranasal ketamine use (50 mg) from age 15 to 17.

Findings:

Cystoscopy revealed lesions consistent with interstitial cystitis.
These findings are similar to those observed in other ketamine abusers.
This case represents a previously unreported presentation of delayed genitourinary symptoms post-ketamine cessation.

Implications:

This case underscores the potential for delayed-onset genitourinary complications following ketamine abuse.
Further research is warranted to understand the pathogenesis of ketamine-induced bladder damage.
Longitudinal follow-up of former ketamine users is crucial for early intervention and management.