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Related Experiment Videos

Group B Streptococcus and the Vaginal Microbiota.

Geoffrey H Rosen1, Tara M Randis2,3,4, Purnahamsi V Desai2,3

  • 1Columbia University College of Physicians and Surgeons.

The Journal of Infectious Diseases
|September 22, 2017
PubMed
Summary

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Group B Streptococcus (GBS) colonization in women is not linked to overall vaginal microbiota diversity. However, specific bacteria within certain community state types are associated with GBS carriage.

Area of Science:

  • Microbiology
  • Vaginal Microbiota
  • Bacterial Pathogenesis

Background:

  • Streptococcus agalactiae, or group B Streptococcus (GBS), is a significant neonatal pathogen and an increasing cause of adult infections.
  • Maternal vaginal colonization is the primary risk factor for neonatal GBS disease.
  • The interplay between GBS and the vaginal microbiota remains poorly understood.

Purpose of the Study:

  • To investigate the relationship between Streptococcus agalactiae (GBS) colonization and the vaginal microbiota composition in nonpregnant women.
  • To identify specific microbial taxa associated with GBS carriage.

Main Methods:

  • Vaginal lavage samples were collected from nonpregnant women.
  • Samples were tested for the presence of GBS.
Keywords:
group B Streptococcusneonatal pathogensvaginal microbiome

Related Experiment Videos

  • Amplicon-based sequencing of the 16S ribosomal RNA V3-V4 region was performed to analyze the vaginal microbiota composition.

    • Main Results:

    • No association was found between GBS carriage and demographic factors, alpha-diversity, or overall vaginal microbiota community state types (CST).
    • GBS positivity was significantly higher in CST IV-A compared to CST IV-B within the non-Lactobacillus-dominant CST IV.
    • Principal coordinates analysis revealed significant clustering by GBS status, with linear discriminant analysis identifying 18 taxa associated with GBS carriage. After adjustment, 4 taxa were positively and 6 negatively associated with GBS.

    Conclusions:

    • Vaginal microbiota community state type and alpha-diversity are not directly related to GBS status.
    • Specific microbial taxa are associated with GBS colonization, suggesting a potential role for the vaginal microbiota in modulating the carriage of this pathogen.