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A PC-PU nanoparticle/PU/decellularized scaffold composite vascular patch: Synergistically optimized overall
Jun Zhang1, Cheng Liu2, Fuling Feng1
1Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of 3D Printing Equipment and Manufacturing, National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, China.
A novel composite vascular patch (PCVP) using nanoparticles, polyurethane, and decellularized scaffold shows excellent biocompatibility and promotes blood vessel repair. This biomaterial offers a promising solution for vascular reconstruction, achieving successful endothelialization in vivo.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Vascular Surgery
Background:
- Autologous, nonautologous, and synthetic vascular patches have limitations.
- There is a need for advanced vascular graft materials with improved biocompatibility and regenerative capacity.
Purpose of the Study:
- To develop and evaluate a novel composite vascular patch (PCVP) for enhanced vascular repair.
- To assess the biocompatibility, mechanical properties, and in vivo performance of the PCVP.
Main Methods:
- Fabrication of the PCVP using a facile cosedimentation method.
- In vitro evaluation of blood and cell compatibility (hemolysis, coagulation, cytotoxicity).
- In vivo assessment of the PCVP in a mouse model, including patency and endothelialization.
Main Results:
- The PCVP demonstrated high biocompatibility and improved anticoagulation activity due to PC-PU nanoparticle surface modification.
- The nanopatterned surface promoted cell attachment, proliferation, migration, and differentiation.
- The decellularized scaffold provided mechanical properties similar to native blood vessels.
- The patched artery remained patent with successful endothelialization 30 days post-implantation.
Conclusions:
- The multilayered PCVP synergistically optimizes performance through its combined components.
- The developed PCVP is a highly biocompatible and effective biomaterial for vascular reconstruction.
- This composite vascular patch represents a promising advancement in addressing the limitations of current vascular graft materials.