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Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Feb 22, 2026

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

[Bone Metastases - Pathophysiology, Diagnostic Testing and Therapy (Part 1)].

Sebastian Koob¹, Michael Kehrer¹, Andreas Strauss¹

¹Klinik und Poliklinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Bonn.

Zeitschrift Fur Orthopadie Und Unfallchirurgie

|September 22, 2017

Summary

Bone metastases significantly complicate cancer treatment, often leading to incurable disease despite improved survival rates. Managing skeletal-related events (SREs) is crucial, even in palliative care, requiring interdisciplinary approaches.

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Last Updated: Feb 22, 2026

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Intra-iliac Artery Injection for Efficient and Selective Modeling of Microscopic Bone Metastasis

Published on: September 26, 2016

Area of Science:

Oncology
Orthopaedic Surgery
Radiology

Background:

Cancer is a leading cause of death in Europe, with bone metastasis frequently indicating incurable disease.
Improved cancer treatments increase patient survival, highlighting the importance of managing skeletal-related events (SREs).
Bone metastases represent a significant clinical challenge, demanding interdisciplinary collaboration.

Purpose of the Study:

To review the pathophysiology of bone metastases.
To outline diagnostic approaches for bone metastases.
To discuss the clinical relevance of managing skeletal-related events (SREs).

Main Methods:

Selective literature review.

Main Results:

Bone metastasis pathophysiology involves complex interactions.
Various diagnostic tools are available for bone metastasis detection.
Effective management of SREs is vital for patient outcomes.

Conclusions:

Understanding bone metastasis pathophysiology is key for effective treatment.
Current diagnostic methods aid in clinical decision-making.
Interdisciplinary management of SREs improves palliative and long-term care for cancer patients.