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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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[Novel Immuno-oncology Therapy: Current Status of Clinical Research and Prospect of Application]

Shijia Zhang1, Shengxiang Ren1

  • 1Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.

Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer
|September 23, 2017
PubMed

Insights

Immune-oncologic therapies offer new cancer treatment options beyond traditional methods. This review explores emerging targets and clinical potential within the cancer-immunity cycle.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Research

Background:

  • Immune-oncologic therapy is a rapidly advancing field in cancer treatment.
  • It is now a recognized treatment modality alongside surgery, radiotherapy, chemotherapy, and targeted therapy.
  • Approved immune checkpoint inhibitors demonstrate efficacy in various malignancies.

Purpose of the Study:

  • To summarize the current research status of novel immune-oncologic therapies.
  • To review the clinical prospects of agents targeting different stages of the cancer-immunity cycle.
  • To highlight emerging therapeutic targets in cancer immunology.

Main Methods:

  • Literature review of recent advancements in immune-oncologic therapy.
  • Analysis of approved immune checkpoint inhibitors and their applications.
  • Identification of novel therapeutic targets within the cancer-immunity cycle.
  • Evaluation of the clinical potential of these novel agents.

Main Results:

  • Several immune checkpoint inhibitors are approved and effective for treating diverse cancers.
  • Numerous potential therapeutic targets within cancer immunity have been identified.
  • Novel immune-oncologic agents targeting various steps of the cancer-immunity cycle are under investigation.

Conclusions:

  • Immune-oncologic therapy represents a significant advancement in cancer treatment.
  • Further research into novel targets and agents holds promise for improved clinical outcomes.
  • Understanding the cancer-immunity cycle is crucial for developing next-generation immunotherapies.

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