Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

663
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
663
Metabolic States of the Body: Fasting and Starvation01:24

Metabolic States of the Body: Fasting and Starvation

3.0K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
3.0K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

5.9K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
5.9K
Bioavailability Study Design: Healthy Subjects Versus Patients01:15

Bioavailability Study Design: Healthy Subjects Versus Patients

172
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
172
Modified-Release Drug Delivery Systems: Bioavailability01:30

Modified-Release Drug Delivery Systems: Bioavailability

31
Modified-release (MR) dosage forms are designed to extend drug release over time, thereby maintaining stable plasma concentrations and reducing dosing frequency. However, their bioavailability is typically below 100% due to incomplete drug release and presystemic metabolism, and limitations in drug permeability across the gastrointestinal epithelium, all of which can restrict the fraction of the drug reaching systemic circulation. Consequently, studying the in vivo bioavailability of MR...
31

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.

Nature genetics·2017
Same author

Relationship between genetic variation at PPP1R3B and levels of liver glycogen and triglyceride.

Hepatology (Baltimore, Md.)·2017
Same author

Body mass index and breast cancer survival: a Mendelian randomization analysis.

International journal of epidemiology·2017
Same author

Liver fat content, non-alcoholic fatty liver disease, and ischaemic heart disease: Mendelian randomization and meta-analysis of 279 013 individuals.

European heart journal·2017
Same author

U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies.

European heart journal·2017
Same author

Plasma urate, lung function and chronic obstructive pulmonary disease: a Mendelian randomisation study in 114 979 individuals from the general population.

Thorax·2017

Related Experiment Video

Updated: Feb 22, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.8K

A Test in Context: Lipid Profile, Fasting Versus Nonfasting.

Børge G Nordestgaard1

  • 1Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Journal of the American College of Cardiology
|September 23, 2017
PubMed
Summary

Nonfasting lipid profiles provide a more accurate assessment of atherogenic lipoproteins compared to traditional fasting tests. This simplification offers significant benefits for cardiovascular disease prevention without compromising diagnostic or therapeutic decisions.

Keywords:
cardiovascular diseasecholesterollipoproteinslow-density lipoproteintriglycerides

More Related Videos

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

3.8K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K

Related Experiment Videos

Last Updated: Feb 22, 2026

Assessing Whole-Body Lipid-Handling Capacity in Mice
07:57

Assessing Whole-Body Lipid-Handling Capacity in Mice

Published on: November 24, 2020

4.8K
Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

3.8K
Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
11:06

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia

Published on: April 7, 2023

2.8K

Area of Science:

  • Cardiovascular Medicine
  • Clinical Chemistry
  • Lipid Metabolism

Background:

  • Traditional lipid profiles require prolonged fasting (>8 hours), which is physiologically uncommon.
  • The nonfasting state represents the majority of a 24-hour cycle and reflects a broader spectrum of lipoprotein levels.
  • Fasting samples capture hepatic lipoproteins, while nonfasting samples also include intestinal lipoproteins.

Purpose of the Study:

  • To evaluate the clinical utility and implications of nonfasting lipid profiles.
  • To compare atherogenic lipoprotein levels in fasting versus nonfasting states.
  • To assess the impact of nonfasting lipid profiles on cardiovascular disease (CVD) risk assessment.

Main Methods:

  • Analysis of maximal mean changes in lipid parameters between random, nonfasting, and fasting blood samples.
  • Review of current guidelines and statements from major medical societies regarding lipid profiling.

Main Results:

  • Nonfasting lipid profiles showed significant mean changes: +26 mg/dl for triglycerides, -8 mg/dl for total cholesterol, -8 mg/dl for LDL cholesterol, +8 mg/dl for remnant cholesterol, and -8 mg/dl for non-HDL cholesterol.
  • Lipoprotein(a), apolipoprotein B, and HDL cholesterol levels were largely unaffected by fasting status.
  • Numerous international guidelines now endorse nonfasting lipid profiles.

Conclusions:

  • Nonfasting lipid profiles offer a practical simplification for patients, laboratories, and clinicians.
  • Adopting nonfasting lipid profiles does not negatively impact prognostic, diagnostic, or therapeutic decisions for CVD prevention.
  • The widespread endorsement of nonfasting lipid profiles by major societies supports their clinical adoption.