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Complete Genome Sequence of Campylobacter jejuni RM1246-ERRC, Which Exhibits Resistance to Quaternary Ammonium

Nereus W Gunther1, Erin R Reichenberger2

  • 1U.S. Department of Agriculture, Agricultural Research Service, Wyndmoor, Pennsylvania, USA jack.gunther@ars.usda.gov.

Genome Announcements
|September 23, 2017
PubMed

Insights

Campylobacter jejuni strain RM1246-ERRC shows increased resistance to quaternary ammonium compounds. This clinical isolate

Area of Science:

  • Microbiology
  • Genomics
  • Antimicrobial Resistance

Background:

  • Campylobacter jejuni is a leading cause of bacterial gastroenteritis worldwide.
  • Antimicrobial resistance in C. jejuni poses a significant public health challenge.
  • Quaternary ammonium compounds are widely used disinfectants.

Purpose of the Study:

  • To characterize the genomic features of Campylobacter jejuni strain RM1246-ERRC.
  • To investigate the antimicrobial resistance profile of strain RM1246-ERRC, particularly against quaternary ammonium compounds.

Main Methods:

  • Whole-genome sequencing of C. jejuni strain RM1246-ERRC.
  • Phenotypic testing of antimicrobial susceptibility to quaternary ammonium compounds.

Main Results:

  • The genome of C. jejuni RM1246-ERRC consists of a 1,659,694 bp chromosome with 30.56% G+C content.
  • A 45,197 bp plasmid was identified in strain RM1246-ERRC.
  • RM1246-ERRC demonstrated enhanced resistance to quaternary ammonium compounds compared to other C. jejuni strains.

Conclusions:

  • Campylobacter jejuni strain RM1246-ERRC possesses unique genomic characteristics.
  • The enhanced resistance of RM1246-ERRC to quaternary ammonium compounds warrants further investigation into resistance mechanisms.

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