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Probiotic reduces bacterial translocation in type 2 diabetes mellitus: A randomised controlled study
Junko Sato1, Akio Kanazawa2,3, Kosuke Azuma1
1Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, 113-8421, Japan.
Scientific Reports
|September 23, 2017
Summary
Probiotics, specifically Lactobacillus casei strain Shirota, reduced bacterial translocation and altered gut microbiota in type 2 diabetes patients. This intervention shows potential for managing gut health in diabetes.
Area of Science:
- Microbiology
- Endocrinology
- Gastroenterology
Background:
- Gut bacterial translocation is linked to insulin resistance in type 2 diabetes.
- Understanding the gut microbiota's role is crucial for diabetes management.
Purpose of the Study:
- To investigate the effect of probiotics on bacterial translocation.
- To analyze changes in gut microbiota composition in type 2 diabetes patients.
Main Methods:
- A 16-week randomized controlled trial involving 70 Japanese type 2 diabetes patients.
- Intervention group received Lactobacillus casei strain Shirota fermented milk; control group received none.
- Fecal and blood microbiota, fecal organic acids, and biochemical parameters were measured.
Main Results:
- Probiotic intake significantly increased fecal counts of Clostridium coccoides and Clostridium leptum subgroups.
- Fecal Lactobacillus counts were significantly higher in the probiotic group.
- Blood bacterial counts were significantly lower in the probiotic group, indicating reduced translocation.
Conclusions:
- Probiotic administration effectively reduced bacterial translocation in type 2 diabetes patients.
- Probiotics altered gut microbiota composition, increasing beneficial bacteria.
- Lactobacillus casei strain Shirota shows promise in managing gut health and potentially insulin resistance in type 2 diabetes.
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