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Related Concept Videos

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In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
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Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
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Related Experiment Video

Updated: Feb 22, 2026

Author Spotlight: Innovative Methodology for Implanting and Securing Neural Probes in the Rodent Spinal Cord
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Artificial sensory organs: latest progress.

Tatsuo Nakamura1, Yuji Inada2,3, Keiji Shigeno2,4

  • 1Laboratory of Organ and Tissue Reconstruction, Department of Regeneration Science and Engineering, Institute for Frontier Life and Medical Sciences, Kyoto University, Shogoin Kawahara-cho 53, Kyoto, 606-8507, Japan. nakamura@frontier.kyoto-u.ac.jp.

Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs
|September 23, 2017
PubMed
Summary
This summary is machine-generated.

Artificial nerves, like the polyglycolic acid collagen (PGA-C) tube, show promise for peripheral nerve repair and regeneration. Clinical results demonstrate effectiveness in treating nerve damage and neuropathic pain.

Keywords:
Artificial nerveArtificial stimulation sensorIn situ tissue engineeringNerve guide tubeNeuropathic pain

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Neuroscience

Background:

  • Peripheral nerve damage presents significant clinical challenges.
  • The inherent regenerative potential of peripheral nerves offers a target for therapeutic intervention.
  • Artificial nerve conduits are being developed to support and guide nerve regeneration.

Purpose of the Study:

  • To present recent advancements in artificial sensory organs, focusing on artificial nerves.
  • To highlight the clinical outcomes of using a specific artificial nerve conduit.
  • To discuss the application of in situ tissue engineering principles in nerve repair.

Main Methods:

  • Utilizing a bio-absorbable polyglycolic acid collagen (PGA-C) tube with a multi-chamber structure.
  • Employing collagen as a filler material within the tube.
  • Clinical application and evaluation of the PGA-C tube for peripheral nerve repair.

Main Results:

  • Over 300 PGA-C tubes have been used clinically in Japan since 2002.
  • Satisfactory results have been reported for peripheral nerve repair using the PGA-C tube.
  • The PGA-C tube has demonstrated efficacy in managing neuropathic pain.

Conclusions:

  • The PGA-C tube represents a viable option for peripheral nerve regeneration.
  • Artificial nerves leveraging tissue engineering principles show clinical promise.
  • This technology offers a potential solution for patients with nerve damage and associated pain.