Immunoglobulin genotypes and cognitive functions in schizophrenia
Janardan P Pandey1, Aryan M Namboodiri2, Paul J Nietert3
1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, 29425, USA. pandeyj@musc.edu.
Immunogenetics
|September 23, 2017
Summary
Specific immunoglobulin (GM and KM) genotypes are linked to cognitive function in schizophrenia patients. These genetic variations influence memory and processing speed, offering new insights into the neurodevelopmental disorder.
Area of Science:
- Neuroscience
- Immunogenetics
- Psychiatry
Background:
- Neurotropic viruses are linked to cognitive impairment in schizophrenia.
- These viruses employ immune evasion strategies, influenced by immunoglobulin (GM) genotypes.
- GM genotypes are associated with schizophrenia susceptibility, suggesting a role in cognitive function.
Purpose of the Study:
- To investigate the association between immunoglobulin (GM and KM) genotypes and cognitive functions in schizophrenia patients.
- To explore the individual and epistatic effects of GM and KM genotypes on cognitive performance.
Main Methods:
- Cognitive functions (verbal memory, working memory, motor speed, verbal fluency, attention, processing speed, executive function) were assessed in 145 schizophrenia patients.
- DNA was analyzed for various GM and KM (κ marker) alleles.
- Statistical analyses were performed to identify genotype-phenotype associations and epistatic effects.
Main Results:
- Specific KM and GM genotypes were significantly associated with verbal memory and attention/processing speed, respectively (P=0.01 and 0.001).
- Epistatic effects between GM and KM genotypes were observed for attention/processing speed, verbal fluency, and motor speed (P=0.031, 0.047, 0.003).
Conclusions:
- Immunoglobulin GM and KM genotypes, individually and epistatically, contribute to cognitive variability in schizophrenia.
- These findings highlight the role of immune system genes in the cognitive deficits associated with schizophrenia.
- Further research on these polymorphic immune genes is warranted.
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