Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gas Chromatography: Types of Detectors-I01:21

Gas Chromatography: Types of Detectors-I

1.7K
There are different types of detectors used in gas chromatography, each with its own specific properties that make it suitable for detecting certain types of analytes. The most commonly used detectors in GC are thermal conductivity detector (TCD), flame ionization detector (FID), and electron capture detector (ECD).
TCD is the earliest and most widely used detector that operates by measuring the changes in the thermal conductivity of the carrier gas. When a sample compound enters the detector,...
1.7K
High-Performance Liquid Chromatography: Types of Detectors01:15

High-Performance Liquid Chromatography: Types of Detectors

1.8K
The role of the detectors in High-Performance Liquid Chromatography (HPLC) is to analyze the solutes as they exit from the chromatographic column. The detector recognizes the solute's property and generates corresponding electrical signals, which are converted into a readable graph of the detector's response versus elution time called a chromatogram at the computer. There are several types of HPLC detectors, each with its own advantages and limitations, depending on the analyte...
1.8K
High-Performance Liquid Chromatography: Elution Process01:05

High-Performance Liquid Chromatography: Elution Process

1.7K
In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
1.7K
Gas Chromatography: Overview of Detectors01:13

Gas Chromatography: Overview of Detectors

2.1K
Detectors in gas chromatography (GC) help identify and quantify the components of a mixture by translating chemical properties into measurable signals, which are displayed on a chromatogram. Detectors can be categorized into two main types: destructive and non-destructive.
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
2.1K
Gas Chromatography: Types of Detectors-II01:19

Gas Chromatography: Types of Detectors-II

1.3K
In gas chromatography, different detectors are employed to meet specific analytical needs. These detectors are often categorized based on their detection mechanisms and the types of compounds they are best suited to analyze. Thermal Conductivity Detectors (TCD), Flame Ionization Detectors (FID), and Electron Capture Detectors (ECD) represent common categories, each with unique operating principles and applications. However, beyond these, several other detectors are designed for more specialized...
1.3K
Electrophoresis: Overview01:20

Electrophoresis: Overview

4.3K
Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case of complete response to immunotherapy in MMR-deficient prostate cancer associated with NK-like and CD4<sup>+</sup>CD8<sup>+</sup> T cells.

Cell reports. Medicine·2026
Same author

Heavy metals in basic vegetables of the Bagerhat district, Bangladesh.

Food additives & contaminants. Part B, Surveillance·2026
Same author

Unmasking the failure: isolation and cohorting practice in low-resource healthcare settings.

The Journal of hospital infection·2026
Same author

MLL4/KMT2D histone methyltransferase and JUNB cooperate in a feed-forward loop to support AP-1-dependent TGF-β signaling.

Genes & development·2026
Same author

Digital addiction among female university students: a cross-sectional study in Dhaka, Bangladesh.

BMC women's health·2026
Same author

A comparative analysis of groundwater quality in a suburban area of Bangladesh.

Scientific reports·2026

Related Experiment Video

Updated: Feb 22, 2026

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

8.5K

A Microwave Flow Detector for Gradient Elution Liquid Chromatography.

Duye Ye1, Weizheng Wang1, David Moline1

  • 1Department of Electrical and Computer Engineering, ‡Department of Food, Nutrition, and Packaging Sciences, Clemson University , Clemson, South Carolina 29634, United States.

Analytical Chemistry
|September 23, 2017
PubMed
Summary
This summary is machine-generated.

A novel microwave flow detector for liquid chromatography (LC) offers high sensitivity, detecting less than 30 ng. This tunable microwave interferometer (MIM) system enhances analytical capabilities for various chemical analyses.

More Related Videos

High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition
05:11

High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition

Published on: June 27, 2025

725
Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
08:01

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection

Published on: December 15, 2015

8.0K

Related Experiment Videos

Last Updated: Feb 22, 2026

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor
09:49

Fast Enzymatic Processing of Proteins for MS Detection with a Flow-through Microreactor

Published on: April 6, 2016

8.5K
High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition
05:11

High-precision Electromagnetic Flowmeter with Empty Pipe Detection via Complex Programmable Logic Device-based Waveform Recognition

Published on: June 27, 2025

725
Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection
08:01

Tuning a Parallel Segmented Flow Column and Enabling Multiplexed Detection

Published on: December 15, 2015

8.0K

Area of Science:

  • Analytical Chemistry
  • Microwave Spectroscopy
  • Chromatography Instrumentation

Background:

  • Traditional detectors in liquid chromatography (LC) face limitations in sensitivity and specificity.
  • Developing advanced detection techniques is crucial for trace analysis and complex sample matrices.

Purpose of the Study:

  • To present a novel microwave flow detector technique for LC applications.
  • To evaluate the performance and capabilities of a tunable microwave interferometer (MIM) based detector.

Main Methods:

  • A microstrip-line-based 0.3 μL flow cell was integrated into a tunable microwave interferometer (MIM).
  • A vector network analyzer (VNA) and computer system were used for signal measurement and control.
  • The detector was tested with common chemicals in DI water across frequencies from 0.98 to 7.09 GHz, and with a caffeine solution on an HPLC system.

Main Results:

  • A minimum detectable quantity (MDQ) of less than 30 ng was achieved.
  • The detector demonstrated a signal-to-noise ratio (SNR) up to 10 for caffeine solutions under various elution conditions.
  • An algorithm was developed to determine sample dielectric permittivity, and automatic MIM tuning was implemented for mobile phase variations.
  • Quantification of coeluted vitamin E succinate (VES) and vitamin D3 (VD3) was demonstrated.

Conclusions:

  • The developed microwave flow detector offers a sensitive and versatile detection method for LC.
  • The MIM-based system shows potential for improved analytical performance, including handling complex mobile phases and resolving coeluted compounds.