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The carcinoid tumour.

J F Thompson, D C Gee, J M Little

    The Australian and New Zealand Journal of Surgery
    |June 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Carcinoid tumors, originating from neural crest APUD cells, can appear throughout the digestive system and its derivatives. This review analyzes 31 cases, detailing diagnosis, treatment, and management of these neuroendocrine neoplasms.

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    Area of Science:

    • Oncology
    • Embryology
    • Gastroenterology

    Background:

    • Carcinoid tumors are neuroendocrine neoplasms originating from amine precursor uptake and decarboxylation (APUD) cells.
    • These APUD cells, derived from the neural crest, migrate extensively during embryonic development.
    • Their migration results in carcinoid tumors occurring in diverse locations within the alimentary tract and its derivatives.

    Observation:

    • A series of 31 carcinoid tumors diagnosed at Royal Prince Alfred Hospital over a five-year period were reviewed.
    • The study examined the distinct clinical and histological characteristics of carcinoid tumors based on their origin (foregut, midgut, hindgut).

    Findings:

    • Carcinoid tumors exhibit varied clinical presentations and histological features depending on their anatomical origin.

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  • Analysis of the 31 cases provided insights into the diagnostic challenges and therapeutic outcomes.

    • Implications:

    • Understanding the origin-specific features of carcinoid tumors is crucial for accurate diagnosis and effective management.
    • Recommendations for patient management are provided, aiming to improve outcomes for individuals with these neuroendocrine neoplasms.