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Related Experiment Video

Updated: Feb 22, 2026

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

A Large Lateral Craniotomy Procedure for Mesoscale Wide-field Optical Imaging of Brain Activity

Published on: May 7, 2017

Brain activation patterns during unilateral premolar occlusion.

Chun-Zhen Feng¹, Jin-Feng Li², Nan Hu¹

¹a Department of Stomatology , Chinese PLA General Hospital , Beijing , China.

Cranio : the Journal of Craniomandibular Practice

|September 23, 2017

Summary

This summary is machine-generated.

Unilateral premolar occlusion activates specific brain regions similar to chewing. Ipsilateral premolar activation patterns showed greater similarity than contralateral patterns, indicating localized brain responses.

Keywords:

Brain activation areas functional magnetic resonance imaging premolar

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Area of Science:

Neuroscience
Neuroimaging
Sensory-motor integration

Background:

Understanding brain activation during mastication is crucial for neuroscience.
Previous research has explored chewing-related brain responses, but specific premolar occlusion effects are less understood.

Purpose of the Study:

To investigate brain activation patterns during unilateral premolar occlusion.
To compare brain responses to occlusion of different premolars (ipsilateral vs. contralateral).

Main Methods:

Functional magnetic resonance imaging (fMRI) was used on 10 healthy volunteers.
Participants underwent occlusion of the left first premolar (L1), left second premolar (L2), and right first premolar (R1).
Analysis focused on key brain regions including the sensorimotor cortex, insula, thalamus, and prefrontal cortex.

Main Results:

Single premolar occlusion activated areas such as the precentral gyrus, postcentral gyrus, cerebellum, thalamus, frontal lobe, hippocampus, cingulate gyrus, and parietal lobe.
Activated brain areas were comparable to those observed during natural chewing.
Brain activation patterns for L1 were more similar to L2 (ipsilateral) than to R1 (contralateral); no significant hemispheric differences were found.

Conclusions:

Brain activation patterns elicited by occluding two ipsilateral premolars were more similar than those from occluding a contralateral premolar.
This suggests a degree of lateralization or specific neural representation for ipsilateral occlusal stimuli.