Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Statistical Significance01:50

Statistical Significance

22.6K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
22.6K
Confirmation Biases01:31

Confirmation Biases

8.3K
The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
8.3K
Causes of Similarity-Dissimilarity Effect01:26

Causes of Similarity-Dissimilarity Effect

275
The similarity-dissimilarity effect, a fundamental concept in social psychology, explains how interpersonal similarities and differences influence attraction and social interactions. This effect is supported by three key psychological perspectives: balance theory, social comparison theory, and consensual validation.Balance Theory and Cognitive ConsistencyBalance theory, developed by Fritz Heider, posits that individuals seek cognitive consistency in their relationships. When two people share...
275
Correspondence Bias01:17

Correspondence Bias

254
Correspondence bias, also referred to as the fundamental attribution error, describes the tendency to attribute another person’s behavior to internal characteristics rather than situational influences. This cognitive bias leads individuals to overlook external factors that may be influencing actions, thereby fostering potentially inaccurate assessments of others’ intentions and dispositions.Empirical Evidence for Correspondence BiasResearch has consistently demonstrated the...
254
Cognitive Learning01:21

Cognitive Learning

1.4K
Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...
1.4K
Theory of Attribution II: Kelley's Covariation Theory01:29

Theory of Attribution II: Kelley's Covariation Theory

714
Attribution theory plays a crucial role in social psychology, helping to explain how individuals interpret the causes of behavior. One prominent model within this field is Harold Kelley's covariation theory, which provides a systematic approach to determining whether internal traits or external circumstances drive a person's actions. The model posits that individuals rely on three key types of information—consensus, consistency, and distinctiveness—to make these judgments.Consensus:...
714

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Utility of the Dicrotic Notch Index in Patients Undergoing Transcatheter Aortic Valve Replacement.

Structural heart : the journal of the Heart Team·2026
Same author

Management of coronary artery disease in patients referred for transcatheter aortic valve replacement.

JTCVS structural and endovascular·2026
Same author

Initial experience with transcatheter aortic valve replacement before and after lung transplant.

JTCVS structural and endovascular·2026
Same author

Predicting Intramyocardial Hemorrhage Before Reperfusion in STEMI Patients With Intrinsically Explainable Artificial Intelligence.

JACC. Advances·2026
Same author

Toward creating "caninized" mice: reconstitution of canine immune cells in immunodeficient mice.

American journal of veterinary research·2026
Same author

Efficacy and clinical safety of TricValve bicaval implantation in patients with cardiac implantable electronic devices.

Revista espanola de cardiologia (English ed.)·2026
Same journal

Heterozygosity for pathogenic variants in familial chylomicronemia syndrome genes: from carrier state to complex trait.

Current opinion in lipidology·2026
Same journal

Premature atherosclerotic cardiovascular disease in the MENA region: economic impact, barriers to care, and policy recommendations for an escalating crisis.

Current opinion in lipidology·2026
Same journal

The role of metabolic profiling and dietary intervention in the early diagnosis and prevention of atherosclerosis.

Current opinion in lipidology·2026
Same journal

A JAK of two trades: beneficial or adverse effects of Janus kinase inhibition for plasma LDL-cholesterol and major adverse cardiovascular events in inflammatory bowel disease patients?

Current opinion in lipidology·2026
Same journal

Inflammation and atherosclerotic cardiovascular disease: where do we go from here?

Current opinion in lipidology·2026
Same journal

HDL and ASCVD: is high HDL-C protective, harmful, or simply misleading?

Current opinion in lipidology·2026
See all related articles

Related Experiment Video

Updated: Feb 22, 2026

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning
05:33

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning

Published on: January 29, 2020

6.5K

Implications of GLAGOV study.

Stephen J Nicholls1, Rishi Puri

  • 1aSouth Australian Health and Medical Research Institute bUniversity of Adelaide, Australia cQuébec Heart & Lung Institute, Québec, Canada dCleveland Clinic Coordinating Center for Clinical Research, Cleveland, Ohio, USA.

Current Opinion in Lipidology
|September 23, 2017
PubMed
Summary
This summary is machine-generated.

Adding PCSK9 inhibition with evolocumab to statin therapy significantly reduces LDL-C and promotes regression of coronary atherosclerosis. This demonstrates a direct link between LDL-C reduction and improved cardiovascular health.

More Related Videos

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

10.8K
Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects
07:36

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects

Published on: November 30, 2018

16.5K

Related Experiment Videos

Last Updated: Feb 22, 2026

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning
05:33

Experimental Paradigm for Measuring the Effect of Induced Emotion on Grammar Learning

Published on: January 29, 2020

6.5K
Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language
09:27

Using Eye Movements Recorded in the Visual World Paradigm to Explore the Online Processing of Spoken Language

Published on: October 13, 2018

10.8K
Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects
07:36

Eye Tracking During Visually Situated Language Comprehension: Flexibility and Limitations in Uncovering Visual Context Effects

Published on: November 30, 2018

16.5K

Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Research

Background:

  • Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition is a new strategy for lowering low-density lipoprotein cholesterol (LDL-C).
  • The effect of PCSK9 inhibition on coronary atherosclerosis in patients already on statin therapy was previously unknown.

Purpose of the Study:

  • To evaluate the impact of PCSK9 inhibition on coronary atherosclerosis progression in statin-treated patients.
  • To assess the relationship between LDL-C levels and coronary atherosclerosis regression.

Main Methods:

  • The GLAGOV trial investigated the effect of evolocumab (a PCSK9 inhibitor) versus placebo.
  • Participants were on at least moderate-intensity statin therapy.
  • Coronary atherosclerosis progression was assessed in relation to LDL-C levels.

Main Results:

  • Evolocumab significantly lowered LDL-C levels (36.6 mg/dl) compared to placebo (93.0 mg/dl).
  • This LDL-C reduction was associated with significant regression of coronary atherosclerosis.
  • A direct correlation was found between achieved LDL-C levels and the extent of disease regression.

Conclusions:

  • Combining evolocumab with statin therapy leads to incremental plaque regression in patients with existing coronary artery disease.
  • These findings offer a biological basis for the observed cardiovascular benefits of evolocumab.
  • PCSK9 inhibition represents a valuable therapeutic option for managing coronary atherosclerosis.