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Biomarkers in vasculitis.

Gulen Hatemi1, Sinem N Esatoglu1, Yusuf Yazici2

  • 1Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey.

Current Opinion in Rheumatology
|September 23, 2017
PubMed
Summary

New biomarkers show promise in diagnosing and monitoring vasculitis. Antineutrophil cytoplasmic antibody type and urinary soluble CD163 levels aid in treatment response and identifying active renal disease.

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Area of Science:

  • Rheumatology
  • Immunology
  • Clinical Diagnostics

Background:

  • Biomarkers are crucial for diagnosing, monitoring, and predicting outcomes in vasculitis.
  • Their application extends to clinical practice and clinical trials.

Purpose of the Study:

  • To review recent literature on novel biomarkers for vasculitis.
  • To discuss the expanding use of established biomarkers in vasculitic conditions.

Main Methods:

  • Literature review of recent publications on vasculitis biomarkers.
  • Analysis of biomarker utility in various vasculitic conditions.

Main Results:

  • Antineutrophil cytoplasmic antibody (ANCA) type predicts relapse and rituximab response in ANCA-associated vasculitis.
  • Urinary soluble CD163 levels show promise for active renal vasculitis.
  • Imaging and fecal calprotectin are valuable for large vessel vasculitis and gastrointestinal involvement in Behçet's syndrome, respectively.

Conclusions:

  • Reviewed biomarkers may advance vasculitis management.
  • Further research is needed to understand pathophysiology and validate biomarkers.
  • Standardized definitions and controlled studies are essential for accurate clinical application.