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Updated: Feb 22, 2026

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Solvent-Free Synthesis and Safener Activity of Sulfonylurea Benzothiazolines
Ying Fu1, Jing-Yi Wang2, Dong Zhang3
1Department of Applied Chemistry, College of Science, Northeast Agricultural University, Harbin 150030, China. fuying@neau.edu.cn.
Abstract:
A series of novel sulfonylurea benzothiazolines was designed by splicing active groups and bioisosterism. A solvent-free synthetic route was developed for the sulfonylurea benzothiazoline derivatives via the cyclization and carbamylation. All compounds were characterized by IR, ¹H-NMR, 13C-NMR, HRMS. The biological activity tests indicated the compounds could protect maize against the injury caused by chlorsulfuron to some extent. The molecular docking result showed that the new compound competed with chlorsulfuron to bind with the herbicide target enzyme active site to attain detoxification.
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