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HLA-DR alpha, -DX alpha, and DR beta III gene association studies in DR3 individuals
J Gorski1, M J Niven, J A Sachs
1Department of Microbiology, University of Geneva Medical School, Switzerland.
Human Immunology
|December 1, 1987
Abstract:
In this study we have examined the results of probing with synthetic oligomers at the DR beta III locus, together with restriction fragment length polymorphisms defined by BglII digestion and a cDNA DR alpha probe, and Taq 1 digestion and a genomic DQ alpha probe. We have demonstrated heterogeneity of the human leukocyte antigen DR3 and close association of the DR alpha, DR beta III, and DX alpha genes. Two DR3-related preferential allelic associations have been identified, which may prove useful in family analysis as well as for investigations of DR3-related diseases.