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Effectiveness of Biology-Based Methods for Inhibiting Orthodontic Tooth Movement. A Systematic Review.
The Journal of Clinical Pediatric Dentistry
|September 23, 2017
Summary
Biology-based methods show limited success in slowing orthodontic tooth movement (OTM). Current evidence is insufficient to confirm efficacy, highlighting the need for more rigorous clinical trials on OTM inhibition.
Area of Science:
- Orthodontics
- Biotechnology
- Pharmacology
Background:
- Orthodontic tooth movement (OTM) is a complex biological process.
- Various experimental methods aim to inhibit or decrease OTM in humans.
- A systematic review is needed to evaluate the effectiveness of these biology-based interventions.
Purpose of the Study:
- To systematically review the effects of biology-based interventions on the rate of orthodontic tooth movement.
- To assess the clinical applicability, orthodontic force, and side effects of these methods.
Main Methods:
- Comprehensive electronic and manual searches were conducted up to January 2016.
- Included clinical trials compared biology-based methods against controls for OTM inhibition.
- Risk of bias was assessed using the Cochrane Collaboration's tool.
Main Results:
- Five studies were included, evaluating pharmacological and low-level laser therapy.
- Oral human Relaxin showed no effect; local tenoxicam inhibited OTM by 10%.
- Low-level laser therapy did not significantly differ from placebo in inhibiting OTM.
Conclusions:
- Current data are insufficient to definitively conclude on the efficacy of pharmacological and laser therapies for OTM inhibition.
- Further well-designed randomized clinical trials are urgently required.
