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Prenatal Exposure to Nonpersistent Endocrine Disruptors and Behavior in Boys at 3 and 5 Years

Claire Philippat1, Dorothy Nakiwala1, Antonia M Calafat2

  • 1Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, University Grenoble Alpes , Grenoble, France.

Environmental Health Perspectives
|September 23, 2017
PubMed

Insights

Prenatal exposure to certain phenols, including bisphenol A (BPA), is linked to behavioral issues in young boys. These findings highlight potential risks associated with endocrine-disrupting chemicals in early development.

Area of Science:

  • Environmental Health
  • Developmental Psychology
  • Toxicology

Background:

  • Previous research indicates sex-specific links between phthalates, bisphenol A (BPA), and child behavior.
  • Limited data exists for other phenols with potential endocrine-disrupting properties in large populations.

Purpose of the Study:

  • To investigate associations between prenatal exposure to phthalates and various phenols and the behavior of male infants.
  • To expand knowledge on the behavioral effects of environmental phenols in a large cohort.

Main Methods:

  • Quantified 11 phthalate metabolites and 9 phenols (including BPA and triclosan) in urine samples from pregnant mothers in the EDEN cohort.
  • Assessed child behavior using the Strength and Difficulties Questionnaire (SDQ) at ages 3.1 and 5.6 years for male infants.

Main Results:

  • Bisphenol A (BPA) exposure was associated with relationship problems at age 3 and hyperactivity-inattention at age 5.
  • Mono-n-butyl phthalate (MnBP) and Monobenzyl phthalate (MBzP) were linked to internalizing behaviors and relationship problems at age 3.
  • Triclosan showed a tendency towards positive association with emotional symptoms at both 3 and 5 years.

Conclusions:

  • Associations between BPA, MnBP, and male infant behavior align with prior research.
  • Further studies are needed to quantify the public health impact of these chemical exposures on child development.
Abstract

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