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A Risk Factor Analysis of Cognitive Impairment in Elderly Patients with Chronic Diseases in a Chinese Population

Ye Li1,2,3,4, Xiang Fang2, Wei-Gang Zhao2

  • 1Department of Gerontology, Shandong University, Jinan, Shandong, China (mainland).

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
|September 23, 2017
PubMed

Insights

Cognitive impairment (CI) in elderly patients with chronic diseases is linked to factors like age and cerebral infarction history. Protective factors include immune cells (B and CD8+), daily living activities, and nutritional assessment scores.

Area of Science:

  • Gerontology
  • Neurology
  • Immunology

Background:

  • Cognitive impairment (CI) is a significant concern in elderly individuals with chronic diseases.
  • Identifying risk factors is crucial for timely intervention and management.

Purpose of the Study:

  • To analyze the risk factors associated with cognitive impairment in elderly patients suffering from chronic diseases.
  • To differentiate between cognitive impairment and normal cognitive function in this population.

Main Methods:

  • A cohort of 385 elderly patients with chronic diseases was divided into cognitive impairment (CI) and normal groups.
  • Standardized assessments including ADL, GDS, MMSE, MoCA, PG-SGA, and MNA were utilized.
  • Logistic regression analysis identified key risk and protective factors for CI.

Main Results:

  • Significant differences were observed in age, education, type 2 diabetes, cerebral infarction history, hearing, and eyesight between groups.
  • The CI group exhibited higher CD4+ cell counts, more hospital admissions, and elevated GDS scores.
  • Immune cells (B and CD8+), ADL, and MNA scores acted as protective factors against CI.

Conclusions:

  • Cerebral infarction history, elevated CD4+ cell counts, frequent hospital admissions, higher GDS scores, and advanced age are identified as significant risk factors for CI.
  • Understanding these factors can guide clinical practice and preventive strategies for cognitive health in elderly patients with chronic conditions.

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