Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

9.0K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MASTR-seq enables multiplexed analysis of short tandem repeats with sequencing.

Cell reports methods·2026
Same author

An integrated view of the structure and function of the human 4D nucleome.

Nature·2025
Same author

Learning induces persistent chromatin loops underlying robust gene expression during memory recall.

bioRxiv : the preprint server for biology·2025
Same author

Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons.

bioRxiv : the preprint server for biology·2025
Same author

Autism spectrum disorder risk genes have convergent effects on transcription and neuronal firing patterns in primary neurons.

Genome research·2025
Same author

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 22, 2026

A Macrophage-Tumor Spheroid Co-Invasion Assay
09:01

A Macrophage-Tumor Spheroid Co-Invasion Assay

Published on: January 24, 2025

1.2K

Dynamic Looping Interactions: Setting the 3D Stage for the Macrophage.

Mayuri Rege1, Jennifer E Phillips-Cremins2

  • 1Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

Molecular Cell
|September 23, 2017
PubMed
Summary

Researchers identified five types of 3D chromatin loops crucial for macrophage gene expression. They also predicted key regulatory factors involved in controlling these important genomic interactions.

More Related Videos

Time-lapse Imaging of Mouse Macrophage Chemotaxis
09:33

Time-lapse Imaging of Mouse Macrophage Chemotaxis

Published on: April 2, 2020

12.4K
Time-lapse 3D Imaging of Phagocytosis by Mouse Macrophages
07:24

Time-lapse 3D Imaging of Phagocytosis by Mouse Macrophages

Published on: October 19, 2018

15.5K

Related Experiment Videos

Last Updated: Feb 22, 2026

A Macrophage-Tumor Spheroid Co-Invasion Assay
09:01

A Macrophage-Tumor Spheroid Co-Invasion Assay

Published on: January 24, 2025

1.2K
Time-lapse Imaging of Mouse Macrophage Chemotaxis
09:33

Time-lapse Imaging of Mouse Macrophage Chemotaxis

Published on: April 2, 2020

12.4K
Time-lapse 3D Imaging of Phagocytosis by Mouse Macrophages
07:24

Time-lapse 3D Imaging of Phagocytosis by Mouse Macrophages

Published on: October 19, 2018

15.5K

Area of Science:

  • Genomics and molecular biology, focusing on chromatin architecture.

Background:

  • 3D chromatin looping is essential for regulating gene expression in a cell-specific manner.
  • Understanding these interactions is key to deciphering cell differentiation processes.

Purpose of the Study:

  • To identify and classify different types of 3D chromatin loops involved in macrophage development.
  • To predict potential regulatory factors that control these chromatin loops.

Main Methods:

  • Annotation of five distinct classes of chromatin loops.
  • Bioinformatic analysis to predict candidate regulatory factors.

Main Results:

  • Successfully categorized five classes of chromatin loops during macrophage differentiation.
  • Generated a list of predicted candidate factors potentially regulating these loops.

Conclusions:

  • The study provides a framework for understanding the role of specific chromatin loop classes in macrophage gene regulation.
  • Identified potential molecular players that could be targeted for further investigation into gene expression control.