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Updated: Feb 22, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
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Body Composition Changes in Severely Burned Children During ICU Hospitalization

Janos Cambiaso-Daniel1,2,3, Ioannis Malagaris2,4, Eric Rivas1,2,5

  • 1Department of Surgery, University of Texas Medical Branch, Galveston, TX.

Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
|September 23, 2017
PubMed

Insights

Severe burn injury hospitalization causes significant lean mass loss, particularly in children's upper extremities. Early upper limb mobilization is crucial for recovery and function restoration.

Area of Science:

  • Pediatric critical care medicine
  • Burn injury research
  • Body composition analysis

Background:

  • Prolonged intensive care unit (ICU) stays post-burn injury lead to physical inactivity and muscle weakness.
  • The specific distribution of body composition changes across different anatomical regions in pediatric burn patients is not well understood.

Purpose of the Study:

  • To evaluate the regional body composition changes in severely burned children during ICU hospitalization.
  • To identify specific areas of muscle and fat mass alteration.

Main Methods:

  • Retrospective chart review of 24 severely burned children admitted between 2000 and 2015.
  • Dual-energy x-ray absorptiometry (DXA) was used to assess bone mineral content, bone density, fat mass, and lean mass at admission and before discharge.
  • Analysis focused on whole-body changes and differential changes between upper and lower extremities, without anabolic interventions.

Main Results:

  • Patients experienced an average whole-body lean mass loss of 3% (p < 0.001).
  • Upper extremities showed a significantly greater lean mass loss (17%) compared to lower extremities (7%) (p < 0.001).
  • A significant whole-body increase in fat mass was observed, with greater accumulation in the truncal region and lower limbs.

Conclusions:

  • ICU hospitalization following severe burns is associated with disproportionately greater lean mass loss in the upper limbs of children.
  • Early mobilization programs should prioritize upper limb exercises to mitigate muscle loss and restore function.
Abstract

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