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Updated: Feb 22, 2026

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Administration of four-factor prothrombin complex concentrate for a life-threatening bleed in a Jehovah's Witness

Jennifer L Cole1, Nathanael D McLeod2

  • 1Department of Pharmacy.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|September 23, 2017
PubMed

: Life-threatening bleeds are medical emergencies that require time-sensitive decision making. Patients of the Jehovah's Witness faith can present a challenging conundrum when their beliefs conflict with modern treatment options for haemorrhage. Providers may not be aware of the grades of acceptance of the newer products outside of packed red blood cells. Researchers present a case of using four-factor prothrombin complex concentrate in a Jehovah's Witness patient in a life-threatening gastrointestinal haemorrhage along with a brief review of the literature.

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