Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Pressure01:24

Blood Pressure

10.6K
The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
10.6K
Measurement of Blood Pressure01:17

Measurement of Blood Pressure

3.5K
Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
3.5K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

4.6K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.6K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

486
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
486
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

443
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
443
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.2K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Kinase-Glo luminescent kinase assay for in vitro determination of PKA activity].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology·2012
Same author

Functional characterization of an arrestin gene on insecticide resistance of Culex pipiens pallens.

Parasites & vectors·2012
Same author

MiR-23a inhibits myogenic differentiation through down regulation of fast myosin heavy chain isoforms.

Experimental cell research·2012
Same author

Let-7b inhibits human cancer phenotype by targeting cytochrome P450 epoxygenase 2J2.

PloS one·2012
Same author

Role of IKK/NF-κB signaling in extinction of conditioned place aversion memory in rats.

PloS one·2012
Same author

Inhibition of poly(ADP-ribose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats.

Pancreas·2012

Related Experiment Video

Updated: Feb 22, 2026

In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption
10:36

In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption

Published on: June 20, 2017

9.1K

Pulse pressure is associated with plasma amyloid-β transport dysfunction.

Yu Jiang1, Suhang Shang1, Pei Li1

  • 1Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University.

Journal of Hypertension
|September 23, 2017
PubMed
Summary

Increased pulse pressure (PP) is linked to higher plasma amyloid-beta 1-40 and lower soluble receptor for advanced glycation end products (sRAGE). This suggests a connection between PP and peripheral amyloid-beta clearance mechanisms.

More Related Videos

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.1K
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
10:19

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Published on: August 14, 2016

9.7K

Related Experiment Videos

Last Updated: Feb 22, 2026

In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption
10:36

In Vitro Assays to Assess Blood-brain Barrier Mesh-like Vessel Formation and Disruption

Published on: June 20, 2017

9.1K
Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
09:31

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Published on: March 7, 2019

11.1K
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
10:19

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Published on: August 14, 2016

9.7K

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Biochemistry

Background:

  • Increased pulse pressure (PP) is a known risk factor for Alzheimer's disease (AD) in older adults.
  • Peripheral amyloid-beta (Aβ) clearance is closely related to Aβ deposition in the brain, a hallmark of AD.

Purpose of the Study:

  • To investigate the association between pulse pressure and plasma amyloid-beta transport function.
  • To explore the relationship between PP and plasma levels of Aβ1-40, Aβ1-42, and key transport proteins like soluble low-density lipoprotein receptor-related protein-1 (sLRP1) and soluble receptor for advanced glycation end products (sRAGE).

Main Methods:

  • A cross-sectional study involving 1118 participants.
  • Quantification of plasma Aβ levels and Aβ transporter expression (sLRP1, sRAGE).
  • Multiple linear regression analyses were used to determine relationships between PP and plasma biomarkers, adjusting for various confounding factors.

Main Results:

  • Pulse pressure was a significant determinant of higher plasma amyloid-beta 1-40 levels (β=0.059, P=0.036).
  • Elevated PP was associated with lower levels of log-transformed sRAGE (β=-0.002, P=0.029), independent of other health metrics.
  • sLRP1 and sRAGE showed positive associations with plasma Aβ1-40, and sRAGE was also positively associated with plasma Aβ1-42.

Conclusions:

  • Higher pulse pressure is associated with increased plasma amyloid-beta 1-40 and decreased sRAGE in individuals not on antihypertensive medication.
  • These findings suggest that pulse pressure may influence peripheral amyloid-beta clearance pathways, potentially contributing to Alzheimer's disease pathogenesis.