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An Orthotopic Murine Model of Human Prostate Cancer Metastasis
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Infiltrating mast cells enhance benign prostatic hyperplasia through IL-6/STAT3/Cyclin D1 signals
1Department of Urology, Xiangya Hospital, Central South University, Changsha, China.
Oncotarget
|September 24, 2017
Summary
Mast cells in benign prostatic hyperplasia (BPH) tissues promote prostate cell growth. Mast cell-derived interleukin-6 (IL-6) activates STAT3/Cyclin D1 signals, suggesting targeting mast cells could be a new BPH therapy.
Area of Science:
- Urology
- Immunology
- Cell Biology
Background:
- Mast cells are found in benign prostatic hyperplasia (BPH) tissues.
- The specific role of mast cells in BPH development is not fully understood.
Purpose of the Study:
- To investigate the role of mast cells in BPH development.
- To explore the molecular mechanisms by which mast cells influence BPH progression.
Main Methods:
- Comparison of mast cell infiltration in human BPH and normal prostate tissues.
- In vitro co-culture of BPH-1 prostate cells and mast cells.
- Analysis of molecular signaling pathways including IL-6, STAT3, and Cyclin D1.
Main Results:
- Increased mast cell presence in BPH tissues compared to normal prostate.
- Mast cells enhance BPH-1 cell proliferation and migration.
- Mast cell-derived IL-6 activates STAT3/Cyclin D1 signaling in BPH-1 cells, promoting proliferation.
- Inhibition of IL-6 or STAT3 partially reverses mast cell-induced BPH-1 cell proliferation.
Conclusions:
- Infiltrating mast cells promote BPH development through the IL-6/STAT3/Cyclin D1 pathway.
- Targeting mast cells may offer a novel therapeutic strategy for BPH.
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