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Related Experiment Video

Updated: Feb 22, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
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Controlling polymer capture and translocation by electrostatic polymer-pore interactions.

Sahin Buyukdagli1, T Ala-Nissila2

  • 1Department of Physics, Bilkent University, Ankara 06800, Turkey.

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Understanding polymer translocation through nanopores requires accounting for electrostatic barriers. A specific salt concentration optimizes polymer capture, with translocation time controlled by membrane charge, pore radius, and salt concentration.

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Area of Science:

  • Nanotechnology
  • Polymer Physics
  • Physical Chemistry

Background:

  • Polymer translocation experiments often involve driving anionic polyelectrolytes, like DNA, through negatively charged nanopores.
  • Modeling polymer capture and translocation necessitates understanding the electrostatic barrier from like-charge polymer-pore interactions.

Purpose of the Study:

  • To characterize the interplay between the electrostatic barrier, electrophoretic drift, and electro-osmotic flow in polymer translocation.
  • To identify conditions that optimize polymer capture probability and control translocation time.

Main Methods:

  • Coupling of mean-field electrohydrodynamic equations with the Smoluchowski formalism.
  • Analysis of distinct ion density regimes and salt screening effects on drift and barrier phenomena.

Main Results:

  • A characteristic salt concentration maximizes the probability of barrier-limited polymer capture.
  • In the barrier-dominated regime, translocation time (τ) increases exponentially with membrane charge and decays exponentially with pore radius and salt concentration.

Conclusions:

  • Altering membrane charge, pore radius, and salt concentration can efficiently control polymer translocation duration.
  • These findings facilitate more accurate measurements of ionic current signals during translocation.