Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase 2/3, Open-label, Randomized, Active-controlled Clinical Trial Evaluating the Safety and Efficacy of Imipenem/Cilastatin/Relebactam in Pediatric Patients From Birth to Less Than 18 Years With Gram-negative Bacterial Infections.

The Pediatric infectious disease journal·2026
Same author

Intravascular Adenomyosis in a Cynomolgus Macaque (Macaca Fascicularis).

Journal of medical primatology·2026
Same author

A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Novel Porcine Model Reveals Two Distinct LGR5 Cell Types during Lung Development and Homeostasis.

American journal of respiratory cell and molecular biology·2024
Same author

A gene edited pig model for studying LGR5<sup>+</sup> stem cells: implications for future applications in tissue regeneration and biomedical research.

Frontiers in genome editing·2024
Same author

A biomechanical assessment of tissue-engineered polymer neo-uteri after orthotopic implantation.

F&S science·2023

Related Experiment Video

Updated: Feb 22, 2026

Tissue Engineering of a Human 3D in vitro Tumor Test System
11:12

Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

21.9K

Animal Models in Tissue Engineering. Part I.

Jorge A Piedrahita1, J Koudy Williams2

  • 11 Comparative Medicine Institute, North Carolina State University , Raleigh, North Carolina.

Tissue Engineering. Part C, Methods
|September 24, 2017
PubMed
Summary
This summary is machine-generated.

Choosing the right animal model is crucial for tissue engineering research and regulatory approval. Each model presents unique advantages and disadvantages that must be carefully considered for successful application.

Keywords:
animal modelsregenerative medicinetissue engineering

More Related Videos

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

13.1K
Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
08:38

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

21.7K

Related Experiment Videos

Last Updated: Feb 22, 2026

Tissue Engineering of a Human 3D in vitro Tumor Test System
11:12

Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

21.9K
The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering
08:53

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

13.1K
Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation
08:38

Engineering Skeletal Muscle Tissues from Murine Myoblast Progenitor Cells and Application of Electrical Stimulation

Published on: March 19, 2013

21.7K

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Translational Science

Background:

  • Animal models are indispensable for advancing tissue engineering research and development.
  • In vitro techniques like 3D printing and bioreactors enable complex construct creation, but in vivo validation is essential.
  • Efficacy and safety testing for regulatory approval necessitates in vivo studies.

Purpose of the Study:

  • To highlight the critical role of animal models in tissue engineering.
  • To discuss the challenges associated with selecting appropriate animal models for specific applications.
  • To emphasize the importance of in vivo testing for method refinement and regulatory compliance.

Main Methods:

  • Review of current practices in animal model selection for tissue engineering.
  • Analysis of the limitations and strengths of various animal models.
  • Discussion of challenges including scale-up, diffusion, infiltration, and physiological differences.

Main Results:

  • Animal models remain vital for tissue engineering, despite in vitro advancements.
  • Selection of an appropriate animal model is complex due to inherent model-specific limitations.
  • Physiological and anatomical differences between species pose significant challenges for direct human disease modeling.

Conclusions:

  • Careful consideration of animal model characteristics is paramount for successful tissue engineering research.
  • Overcoming challenges in animal model selection is key to advancing regenerative medicine therapies.
  • In vivo testing in relevant animal models is non-negotiable for clinical translation and regulatory success.