Oropharyngeal lymphoma: A US population based analysis
Hani M Rayess1, Michael Nissan1, Amar Gupta1
1Department of Otolaryngology - Head and Neck Surgery, Wayne State University School of Medicine, Detroit, MI, USA.
Oral Oncology
|September 24, 2017
Summary
Oropharyngeal lymphoma most often starts in the tonsil, with diffuse large B-cell lymphoma (DLBCL) being common. Advanced age, B symptoms, and T-cell tumors indicate a worse prognosis for oropharyngeal lymphoma patients.
Area of Science:
- Oncology
- Epidemiology
- Head and Neck Surgery
Background:
- Oropharyngeal lymphoma is a significant health concern.
- Understanding its epidemiology and survival factors is crucial for patient management.
Purpose of the Study:
- To describe the epidemiology of oropharyngeal lymphoma.
- To analyze factors affecting survival in patients with oropharyngeal lymphoma.
Main Methods:
- Utilized the Surveillance Epidemiology and End Results (SEER) database.
- Analyzed demographic, staging, histopathology, and location data from 2504 patients.
- Employed multivariate regression analysis to identify survival determinants.
Main Results:
- Diffuse large B-cell lymphoma (DLBCL) is the most common subtype (56.9%), often originating in the tonsil (71%).
- Factors significantly associated with decreased survival include advanced patient age, higher Ann Arbor stage, presence of B symptoms, and T-cell histopathology.
- Tumors originating from the soft palate showed a significantly higher likelihood of disease-related death.
Conclusions:
- Oropharyngeal lymphoma predominantly arises from the tonsil, with DLBCL being the most frequent and generally favorable subtype.
- The presence of B symptoms, soft palate origin, and T-cell tumors are associated with a poorer prognosis.
- Findings offer valuable insights for head and neck surgeons counseling patients on oropharyngeal lymphoma prognosis.
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