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Related Experiment Videos

Another trial that failed.

C C Cook1, T D Scannell, M S Lipsedge

  • 1Department of Psychiatry, United Medical School, Guy's Hospital, London.

Lancet (London, England)
|March 5, 1988
PubMed
Summary
This summary is machine-generated.

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This study on opioid withdrawal management using clonidine and lofexidine was terminated due to non-scientific issues. These challenges highlight the practical difficulties in conducting clinical trials for addiction treatments.

Area of Science:

  • Pharmacology
  • Clinical Research
  • Addiction Medicine

Background:

  • Opioid withdrawal syndrome (OWS) management is critical.
  • Clonidine and lofexidine are potential treatments for OWS.
  • Clinical trials face multifaceted challenges beyond scientific merit.

Purpose of the Study:

  • To compare the efficacy of clonidine and lofexidine in managing OWS.
  • To identify and document non-scientific barriers encountered during the trial.

Main Methods:

  • A double-blind, comparative clinical trial design.
  • Inclusion of patients experiencing opioid withdrawal syndrome.
  • Administration of clonidine and lofexidine for symptom management.

Main Results:

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  • The trial was prematurely terminated due to numerous non-scientific obstacles.
  • Issues included research bed availability, patient self-discharge, staff attitudes, and logistical problems.
  • Commercial discontinuation of lofexidine and withdrawal of funding also contributed to termination.

Conclusions:

  • Non-scientific factors significantly impacted the trial's progression and completion.
  • The study underscores the vulnerability of clinical research to external, non-scientific variables.
  • Further research into OWS treatments requires robust planning to mitigate such practical challenges.