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Kidney involvement in psoriasis: a case-control study from China.

Fang Ren1,2, Min Zhang1,2, Liying Hao1,2

  • 1Southern Medical University, Guangzhou, China.

International Urology and Nephrology
|September 24, 2017
PubMed
Summary
This summary is machine-generated.

Psoriasis patients show higher rates of abnormal urinalysis, including increased albuminuria and proteinuria. This suggests potential subclinical kidney dysfunction linked to psoriasis severity.

Keywords:
AlbuminuriaKidney involvementProteinuriaPsoriasis

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Area of Science:

  • Nephrology
  • Dermatology
  • Clinical Medicine

Background:

  • Psoriasis is a chronic inflammatory disease with potential systemic manifestations.
  • Kidney involvement in psoriasis is debated, necessitating further investigation into subclinical renal dysfunction.

Purpose of the Study:

  • To determine the prevalence of urinary abnormalities in psoriasis patients.
  • To assess the relationship between psoriasis severity and the presence of these abnormalities.

Main Methods:

  • A cohort of 97 psoriasis patients and 96 matched controls were analyzed.
  • Psoriasis severity was quantified using the Psoriasis Area and Severity Index (PASI).
  • Urinary markers including 24-hour proteinuria, albuminuria, RBP, and NAG were measured.

Main Results:

  • Psoriasis patients exhibited significantly higher levels of 24-hour microalbuminuria and proteinuria compared to controls.
  • A greater prevalence of pathological albuminuria, NAG, and RBP was observed in psoriasis patients.
  • Psoriasis Area and Severity Index (PASI) scores positively correlated with 24-hour albuminuria.

Conclusions:

  • Abnormal urinalysis findings are more frequent in individuals with psoriasis.
  • The correlation between albuminuria and psoriasis severity suggests subclinical renal impairment in these patients.