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MicroRNAs in cutaneous lichen planus
A A El-Rifaie1, L A Rashed2, R W Doss1
1Dermatology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt.
Clinical and Experimental Dermatology
|September 24, 2017
Summary
This study found lower levels of microRNA (miR)-203 and miR-125b in patients with cutaneous lichen planus (LP). These microRNAs may play a role in the development of this chronic autoimmune skin disease.
Area of Science:
- Dermatology
- Molecular Biology
- Immunology
Background:
- Lichen planus (LP) is a chronic, inflammatory, papulosquamous, autoimmune skin condition.
- The complex pathogenesis of LP involves genetic, environmental, and lifestyle factors.
- MicroRNAs (miRNAs) are implicated in the pathogenesis of inflammatory skin diseases.
Purpose of the Study:
- To investigate the expression levels of miR-203 and miR-125b in cutaneous LP.
- To evaluate the potential role of these specific microRNAs in the pathogenesis of LP.
Main Methods:
- The study included 40 patients with cutaneous LP and 40 age- and sex-matched healthy controls.
- Skin biopsies were obtained from LP lesions and healthy control skin.
- Reverse transcription PCR was used to quantify the mRNA expression of miR-203 and miR-125b.
Main Results:
- Both miR-203 and miR-125b mRNA expression were significantly lower in LP biopsies compared to healthy controls (P < 0.001).
- No correlation was observed between miR-203 or miR-125b expression and patient age, sex, presence of mucosal lesions, or HCV antibody status.
Conclusions:
- Reduced expression of miR-125b and miR-203 may be involved in the pathogenesis of cutaneous lichen planus.
- Further research is warranted to elucidate the precise mechanisms by which these microRNAs contribute to LP development.
