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Published on: April 26, 2019
Perianal pseudoverrucous papules and nodules in Hirschsprung's disease: Rapid resolution with oral loperamide
Francis H X Yap1, Graham Thom2
1Department of Dermatology, Royal Perth Hospital, Perth, WA, Australia.
Insights
A rare case of perianal pseudoverrucous papules and nodules in a child with Hirschsprung's disease resolved with loperamide. This condition, linked to Giardia infection and persistent diarrhea, highlights the importance of addressing skin irritation sources.
Area of Science:
- Pediatric Gastroenterology
- Dermatology
- Infectious Diseases
Background:
- Hirschsprung's disease can lead to complications like persistent diarrhea and stool leakage.
- Giardia infection is a potential trigger for secondary perianal skin conditions.
- Perianal pseudoverrucous papules and nodules are a rare manifestation, potentially severe.
Abstract:
We report the case of a 2-year-old boy with Hirschsprung's disease who developed perianal pseudoverrucous papules and nodules subsequent to persistent diarrhea and stool leakage after Giardia infection. Bleeding from the papules resulted in iron deficiency anaemia requiring blood transfusion and iron infusion. Topical therapies used over 6 months were of limited benefit and colostomy was considered, but the condition completely resolved after commencement of oral loperamide. This demonstrates that perianal pseudoverrucous papules and nodules can be severe but are entirely reversible upon removal of the source of skin irritation.
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