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Published on: June 15, 2019
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Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure
Bradley S Podd1, Dennis W Simon1, Santiago Lopez2
1Department of Critical Care Medicine, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 4400 Penn Avenue, Pittsburgh, PA 15214, USA.
Pediatric Clinics of North America
|September 25, 2017
Summary
Personalized therapies targeting specific inflammation phenotypes may improve outcomes for pediatric sepsis-induced multiple organ failure. This approach combines adjunctive anti-inflammatory and immune modulation with standard care for better results.
Area of Science:
- Pediatric critical care medicine
- Immunology
- Sepsis research
Background:
- Pediatric sepsis-induced multiple organ failure involves complex inflammation.
- At least 5 distinct inflammation pathobiology phenotypes are recognized.
- Current treatments focus on organ support and infection control.
Purpose of the Study:
- To explore host-pathogen interactions in pediatric sepsis.
- To provide a rationale for personalized adjunctive therapies.
- To review anti-inflammatory and immune modulation strategies.
Main Methods:
- Literature review of adjunctive therapies for sepsis phenotypes.
- Analysis of host-pathogen interaction prototypes.
- Discussion of precision medicine in pediatric critical care.
Main Results:
- Adjunctive therapies are proposed for multiple sepsis phenotypes.
- Understanding host-pathogen interactions informs personalized treatment.
- Personalized medicine integrates novel therapies with standard care.
Conclusions:
- Personalized precision medicine offers a promising approach for pediatric sepsis.
- Tailoring therapies to specific inflammation phenotypes is key.
- Adjunctive anti-inflammatory and immune modulation strategies warrant further investigation.
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