Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

550
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
550
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

510
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
510
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

634
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
634
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.1K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.1K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

675
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
675
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

628
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
628

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extraction of Protruding Ostial Stents to Enable Percutaneous Coronary Interventions: The EXPOSE Technique.

JACC. Case reports·2026
Same author

Comparison of Two Pulsed Field Ablation Systems for Atrial Fibrillation: One-Year Outcomes From a Multicenter Registry.

Journal of cardiovascular electrophysiology·2026
Same author

Dosing of single-shot pulsed field ablation systems: A systematic review of efficacy and safety balance.

Heart rhythm·2026
Same author

Spontaneous Coronary Artery Dissection or Coronary Atherosclerosis: Diagnostic Challenges in an Unclear Case.

JACC. Case reports·2026
Same author

Efficacy of Aficamten in Hypertrophic Cardiomyopathy Patients With Very-High Left Ventricular Outflow Tract Gradients.

The American journal of cardiology·2026
Same author

Contemporary coronary physiology practice: An international survey of interventional cardiologists.

Cardiovascular revascularization medicine : including molecular interventions·2026
Same journal

Percutaneous Coronary Intervention Prior to Transcatheter Aortic Valve Implantation: A Bayesian Meta-Analysis of Randomized Controlled Trials.

The Canadian journal of cardiology·2026
Same journal

Practical approach to the assessment of technical scanning skills in transthoracic echocardiography.

The Canadian journal of cardiology·2026
Same journal

Cost-effectiveness of Pharmacist- and Nurse Practitioner-led Medication Management for Heart Failure With Reduced Ejection Fraction.

The Canadian journal of cardiology·2026
Same journal

Rethinking Pacing After Transcatheter Aortic Valve Implantation to Preserve Ventricular Function.

The Canadian journal of cardiology·2026
Same journal

High Intensity Interval Training Versus Moderate Continuous Training in Adults with Congenital Heart Disease: A Randomized Controlled Trial.

The Canadian journal of cardiology·2026
Same journal

Four-Chamber Myocardial Strain to Predict Mortality in Pulmonary Embolism.

The Canadian journal of cardiology·2026
See all related articles

Related Experiment Video

Updated: Feb 22, 2026

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

6.2K

New Developments in Hypertrophic Cardiomyopathy.

Robert M Cooper1, Claire E Raphael2, Max Liebregts3

  • 1Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, United Kingdom.

The Canadian Journal of Cardiology
|September 25, 2017
PubMed
Summary
This summary is machine-generated.

Hypertrophic cardiomyopathy (HCM) management advances include improved imaging and risk stratification for sudden cardiac death. New therapies, including novel medications and septal reduction techniques, show promise for this complex heart condition.

More Related Videos

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.7K

Related Experiment Videos

Last Updated: Feb 22, 2026

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level
06:02

An Approach to Study Shape-Dependent Transcriptomics at a Single Cell Level

Published on: November 2, 2020

6.2K
Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K
Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

10.7K

Area of Science:

  • Cardiology
  • Genetics
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary cause of sudden cardiac death in young people and a significant contributor to heart failure.
  • HCM is a genetically driven, heterogeneous cardiac disease characterized by unexplained left ventricular hypertrophy.

Purpose of the Study:

  • To review recent advancements in the investigation and management of hypertrophic cardiomyopathy.
  • To highlight emerging diagnostic and therapeutic strategies for HCM.

Main Methods:

  • Review of current literature on cardiac imaging, risk stratification, and therapeutic interventions for HCM.
  • Analysis of data from multicentre registries regarding sudden cardiac death and septal reduction therapies.

Main Results:

  • Cardiac magnetic resonance imaging offers detailed insights into myocardial architecture and function.
  • Multicentre registries improve risk stratification for sudden cardiac death, aiding implantable defibrillator decisions.
  • Nonsurgical septal reduction therapies, including alcohol and radiofrequency ablation, show promise, complementing surgical myectomy and mitral valve repair.

Conclusions:

  • Advances in cardiac imaging and risk stratification models enhance HCM management.
  • Emerging therapeutic options, including novel pharmacologic agents and refined interventional procedures, offer new hope for patients with HCM.
  • Personalized treatment strategies are crucial for optimizing outcomes in this complex disease.