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Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28
M Kambouris1, S R Dlouhy, J A Trofatter
1Department of Medical Genetics, Indiana University School of Medicine, Indianapolis 46223.
American Journal of Medical Genetics
|January 1, 1988
Abstract:
X-linked nephrogenic diabetes insipidus (NDI) was segregating in a large Indiana family. It was tested for linkage of the NDI gene to X-chromosome molecular markers. Maximum lod scores of 3.15 and 3.01 (theta = 0) obtained for the molecular markers F8A (F8C) and DXS15 (DX13) respectively, indicate that the NDI gene is located in Xq28. A lod score of 3.61 (theta = 0) was obtained with multipoint linkage analysis of F8A and DXS15.