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[Effects and side effects of somatostatin]
G Steiner1, W Seeling, V Schusdziarra
1Universitätsklinik für Anaesthesiologie, Universität Ulm.
Der Anaesthesist
|December 1, 1987
Summary
Somatostatin, a peptide hormone, regulates gastrointestinal secretions and hormone release. Recent research suggests it may also act as a potent analgesic, though animal studies show significant side effects.
Area of Science:
- Neuroendocrinology
- Gastroenterology
- Pharmacology
Context:
- Somatostatin, a peptide hormone discovered in 1973, is widely distributed in the nervous system and endocrine tissues.
- It functions as a neurotransmitter, local factor, and hormone, influencing numerous physiological processes.
- Its metabolic effects, including inhibition of gastrointestinal secretions and nutrient absorption, are well-documented.
Purpose:
- To compare the known effects of somatostatin with its potential analgesic properties.
- To review the observed side-effects of somatostatin, particularly in the context of its potential use as an analgesic.
- To provide a comprehensive overview of somatostatin's multifaceted roles in the body.
Summary:
- Somatostatin inhibits gastrointestinal secretions, delays nutrient absorption, and modulates hormones involved in water-electrolyte balance.
- In the nervous system, it acts as a neurotransmitter, influencing motor function and behavior.
- Emerging evidence suggests somatostatin may possess potent analgesic properties, warranting further investigation.
Impact:
- Understanding somatostatin's dual roles in metabolic regulation and potential pain relief can inform therapeutic strategies.
- Knowledge of somatostatin's side effects, including hyperglycemia and neurological changes, is crucial for safe clinical application.
- This research highlights somatostatin as a significant molecule with broad physiological implications and therapeutic potential.