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Related Experiment Video

Updated: Feb 22, 2026

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Functional networks and network perturbations in rodents.

Kai-Hsiang Chuang1, Fatima A Nasrallah2

  • 1Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4072, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD 4072, Australia.

Neuroimage
|September 25, 2017
PubMed
Summary

Resting-state functional MRI (rsfMRI) reveals brain networks in rodents, mirroring human connectivity. This allows studying brain function, disease models, and treatments in mice and rats.

Keywords:
Brain connectomeFunctional MRIFunctional connectivityResting state networkTranslational research

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Area of Science:

  • Neuroscience
  • Brain Imaging
  • Connectomics

Background:

  • Synchronous low-frequency oscillations form functional brain networks in humans, mapped via resting-state functional MRI (rsfMRI).
  • Similar resting-state networks, including default mode-like networks, are observable in anesthetized rodent brains.

Purpose of the Study:

  • To review resting-state networks in rat and mouse brains.
  • To explore factors influencing these networks, including pharmacology, stimulation, genetics, and neuroplasticity.
  • To discuss applications in neurological and psychiatric disease models.

Main Methods:

  • Review of existing literature on rodent resting-state networks.
  • Analysis of factors affecting rsfMRI connectivity measures.
  • Discussion of applications in disease modeling.

Main Results:

  • Resting-state networks are detectable in rodent brains, offering translational research opportunities.
  • Anesthesia, genetics, and physiological factors influence rsfMRI measures.
  • Rodent models provide insights into brain connectivity relevant to human diseases.

Conclusions:

  • Rodent models are valuable for understanding the neurophysiological basis of rsfMRI signals and brain connectivity.
  • These models facilitate research into neurological and psychiatric disorders and potential treatments.
  • Careful consideration of methodological factors is crucial for reliable rsfMRI research in rodents.