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The big parade: emerging percutaneous mitral and tricuspid valve devices

Dinesh Natarajan1, Jubin Joseph, Paolo Denti

  • 1St. Thomas' Hospital, London, United Kingdom.

Eurointervention : Journal of Europcr in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
|September 25, 2017
PubMed

Insights

Percutaneous mitral and tricuspid valve interventions are emerging as critical treatments for complex valve diseases. This review details current device technologies and human use data for these challenging conditions.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Biomedical Engineering

Background:

  • Transcatheter aortic valve replacement (TAVR) is now a standard treatment for aortic stenosis, with over 300,000 procedures globally.
  • Significant unmet clinical needs persist for patients with mitral and tricuspid valve disease.
  • The complex anatomy of the mitral and tricuspid valves presents unique therapeutic challenges.

Purpose of the Study:

  • To review the technical characteristics of devices for percutaneous mitral and tricuspid valve interventions.
  • To summarize current human use data for these emerging therapies.
  • To highlight the evolving landscape of structural heart disease interventions.

Main Methods:

  • Review of technical device specifications for mitral and tricuspid valve interventions.
  • Synthesis of available clinical trial and registry data.
  • Analysis of preclinical studies evaluating novel device concepts.

Main Results:

  • A growing number of devices are in preclinical and early clinical evaluation for mitral and tricuspid valve disease.
  • Current devices target various pathologies including leaflet, annular, and chordal issues.
  • Data on human application is accumulating, guiding further development.

Conclusions:

  • Percutaneous interventions for mitral and tricuspid valves represent the next frontier in structural heart disease.
  • Device innovation is rapidly advancing to address complex valve pathologies.
  • Clinical data is crucial for establishing the safety and efficacy of these novel treatments.

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