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Updated: Feb 22, 2026

Observational Study Protocol for Repeated Clinical Examination and Critical Care Ultrasonography Within the Simple Intensive Care Studies
Published on: January 16, 2019
Clinical research in critical care. Difficulties and perspectives
1Servicio de Medicina Intensiva, Hospital General Universitario de Elche, Elche, España; Departamento de Medicina Clínica, Universidad Miguel Hernández, Sant Joan d'Alacant, España.
Abstract:
In the field of Intensive Care Medicine, improved survival has resulted from better patient care, the early detection of clinical deterioration, and the prevention of iatrogenic complications, while research on new treatments has been followed by an overwhelming number of disappointments. The origins of these fiascos must be sought in the conjunction of methodological problems - common to other disciplines - and the particularities of critically ill patients. The present article discusses both aspects and suggests some options for progress.
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