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Hyperhomocysteinemia as a Risk Factor for Saccular Intracranial Aneurysm: A Cohort Study in a Chinese Han Population

Jin-Rui Ren1, Shao-Hua Ren2, Bo Ning3

  • 1Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing, China; Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China; Department of Neurosurgery, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|September 26, 2017
PubMed

Insights

High homocysteine levels are linked to intracranial aneurysms. Folate and Vitamin B12 may protect against aneurysms by regulating homocysteine metabolism.

Area of Science:

  • Neurology
  • Biochemistry
  • Vascular Medicine

Background:

  • Investigated the relationship between serum total homocysteine, folate, and Vitamin B12 in patients diagnosed with intracranial aneurysm.
  • Assessed potential correlations between these biomarkers and the presence of intracranial aneurysms.

Purpose of the Study:

  • To determine the association between serum total homocysteine, folate, and Vitamin B12 levels and intracranial aneurysms.
  • To identify homocysteine as a potential risk factor for intracranial aneurysm development.

Main Methods:

  • Enrolled 140 patients with intracranial aneurysm and 140 controls from the Han population.
  • Measured serum total homocysteine, folate, and Vitamin B12 levels.
  • Analyzed associations using multivariate logistic analysis.

Main Results:

  • Patients with intracranial aneurysms had significantly higher serum total homocysteine levels (19.98 ± 10.84 µmol/L) compared to controls (15.13 ± 5.55 µmol/L).
  • Serum homocysteine showed a negative correlation with folate (r = -0.349) and Vitamin B12 (r = -0.531).
  • Elevated homocysteine presented an adjusted odds ratio of 2.196 for intracranial aneurysm development.

Conclusions:

  • Hyperhomocysteinemia is an independent risk factor for intracranial aneurysms.
  • Folate and Vitamin B12 appear protective against intracranial aneurysms.
  • These vitamins play a role in regulating homocysteine metabolism, influencing aneurysm risk.
Abstract

Keywords:
Intracranial aneurysmVitamin B(12)folatefolic acidhomocysteinehyperhomocysteinemiarisk factor

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