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Retinal microcirculation imaging in sickle cell disease patients.

W Birkhoff1, J de Vries1, G Dent2

  • 1Centre for Human Drug Research, Leiden, The Netherlands.

Microvascular Research
|September 26, 2017
PubMed
Summary

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Non-invasive retinal function imaging (RFI) is a feasible method for assessing microvascular function in sickle cell disease (SCD). RFI demonstrated low variability and significant differences between SCD patients and healthy controls.

Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Medical Imaging

Background:

  • Sickle cell disease (SCD) affects microvascular function.
  • Quantitative assessment of microvascular function is crucial for SCD management.
  • Non-invasive methods are needed for reliable microvascular assessment.

Purpose of the Study:

  • To evaluate the feasibility of non-invasive retinal function imaging (RFI) for quantitative microvascular assessment.
  • To compare RFI with Laser Speckle Contrast Imaging (LSCI) in sickle cell disease (SCD) patients and healthy controls.
  • To determine the repeatability and discriminating power of RFI.

Main Methods:

  • Assessed microvascular measurement variability in 8 SCD patients and 8 healthy controls.
  • Performed RFI for retinal arterial and venous blood flow.

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  • Utilized LSCI for post-occlusive reactive hyperemia and IBH challenges.

    • Main Results:

    • RFI and LSCI showed excellent intra-subject repeatability.
    • Significant differences in RFI arterial and venous flow were observed between SCD patients and controls.
    • LSCI also demonstrated significant differences during IBH challenges.

    Conclusions:

    • RFI exhibits low variability, comparable to LSCI.
    • RFI effectively differentiates microvascular function between SCD patients and controls.
    • RFI is a feasible tool for quantitative microcirculation assessment in clinical research.