Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Association Areas of the Cortex01:21

Association Areas of the Cortex

9.8K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative omics directed gene discovery and rewiring for normal temperature-adaptive red pigment synthesis by polar psychrotrophic fungus <i>Geomyces</i> sp. WNF-15A.

Synthetic and systems biotechnology·2024
Same author

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.

The Journal of steroid biochemistry and molecular biology·2024
Same author

Sigma-1 receptor exerts protective effects on ameliorating nephrolithiasis by modulating endoplasmic reticulum-mitochondrion association and inhibiting endoplasmic reticulum stress-induced apoptosis in renal tubular epithelial cells.

Redox report : communications in free radical research·2024
Same author

SPP1 promotes the polarization of M2 macrophages through the Jak2/Stat3 signaling pathway and accelerates the progression of idiopathic pulmonary fibrosis.

International journal of molecular medicine·2024
Same author

Machine learning and 4D-LFQ quantitative proteomic analysis explore the molecular mechanism of kidney stone formation.

Heliyon·2024
Same author

Based on machine learning, CDC20 has been identified as a biomarker for postoperative recurrence and progression in stage I & II lung adenocarcinoma patients.

Frontiers in oncology·2024

Related Experiment Video

Updated: Feb 22, 2026

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

2.4K

Two cortical deficits underlie amblyopia: A multifocal fMRI analysis.

Reza Farivar1, Jiawei Zhou2, Yufeng Huang3

  • 1McGill Vision Research, Dept. Ophthalmology, McGill University, The Research Institute of the McGill University Health Centre, Montreal, PQ, Canada.

Neuroimage
|September 26, 2017
PubMed
Summary

This study investigated amblyopia, a vision disorder. Using fMRI, researchers found two independent cortical deficits in amblyopic eyes: reduced responsiveness and spatial representation fidelity.

Keywords:
AmblyopiaBOLDDistortionMultifocalVisual acuity

More Related Videos

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.1K
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

880

Related Experiment Videos

Last Updated: Feb 22, 2026

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping
07:11

Author Spotlight: Insights into Visual Cortex Research Through Wide-View fMRI Mapping

Published on: December 8, 2023

2.4K
Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

27.1K
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

880

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Developmental Biology

Background:

  • Amblyopia, or 'lazy eye,' is a common developmental disorder affecting 3% of children, leading to vision loss due to disrupted visual development.
  • Characterized by monocular vision deficits of cortical origin, the exact nature of processing impairments, such as reduced contrast sensitivity and spatial distortions, remains debated.

Purpose of the Study:

  • To determine if the contrast sensitivity loss and spatial distortions in anisometropic amblyopia stem from a single cause or independent cortical disorders.
  • To investigate the neural underpinnings of these deficits using advanced functional magnetic resonance imaging (fMRI).

Main Methods:

  • Employed a multifocal fMRI approach to examine brain activity in response to visual stimulation in individuals with anisometropic amblyopia.
  • Compared fMRI signal magnitudes and the spatial co-localization of activated brain regions between the amblyopic and fellow-fixing eyes.

Main Results:

  • Observed attenuated fMRI signal magnitudes when stimulating the amblyopic eye.
  • Found poor fidelity in the co-localization of activity clusters between amblyopic and fellow-fixing eye stimulation.
  • These effects were correlated with amblyopia severity but not with each other, suggesting independent deficits.

Conclusions:

  • The findings suggest two distinct cortical deficits in amblyopia: reduced neural responsiveness and impaired spatial representation fidelity.
  • These deficits appear independent of each other and consistent across early visual cortical areas, irrespective of eccentricity within the central visual field.