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Tamoxifen-induced Lung Injury
Satoshi Etori1, Ryoji Nakano1, Hideki Kamada2
1Department of Respiratory Medicine, Kin-i-Kyo Chuo Hospital, Japan.
Tamoxifen, a drug used for breast cancer, can rarely cause lung injury. This case highlights the importance of considering tamoxifen-induced lung injury in patients with respiratory symptoms after treatment.
Area of Science:
- Oncology
- Pulmonology
- Pharmacology
Background:
- Tamoxifen is a widely used adjuvant therapy for breast cancer.
- Drug-induced lung injury (DILI) is a known but rare adverse effect of various medications.
Observation:
- A 74-year-old male patient treated for right breast cancer developed cough and dyspnea.
- Chest CT revealed ground-glass opacities in the right lower lung lobe.
Findings:
- The patient was diagnosed with tamoxifen-induced lung injury.
- Diagnosis was confirmed by excluding other causes and observing symptom recurrence upon tamoxifen re-administration.
Implications:
- Physicians should maintain a high index of suspicion for tamoxifen-induced lung injury in patients presenting with respiratory symptoms.
- Early recognition and diagnosis are crucial for appropriate patient management and to prevent further lung damage.
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